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http://dx.doi.org/10.1038/s41422-022-00762-3 | DOI Listing |
Microbiol Spectr
September 2025
Department of Plant Pathology, University of California Davis, Davis, California, USA.
The complex includes high-priority, multidrug-resistant pathogens for which novel antibiotics are urgently needed. Many bacterial strains from this complex harbor a so-called gene cluster that codes for the catabolism of indole-3-acetic acid (IAA). Here, we demonstrate that possession and expression of genes represent an Achilles' heel for species, which can be exploited to suppress bacterial growth by treatment with IAA and its analog 5-chloro-IAA.
View Article and Find Full Text PDFMetab Eng
November 2025
INRAE, INSA Lyon, BF2I, UMR0203, Villeurbanne, France. Electronic address:
Many herbivorous insects feed on unbalanced diets and rely on bacterial endosymbionts to meet all their nutritional needs. This is the case for the pea aphid (Acyrthosiphon pisum), a plant pest whose remarkable growth and reproductive capacities cannot be sustained by its sole nutritional resource, the plant phloem sap, and which relies on a symbiotic relationship maintained over millions of years with the intracellular bacterium Buchnera aphidicola for the biosynthesis of amino acids and vitamins. Exploiting original experimental data and metabolic reconstructions, we have built a quantitative genome-scale metabolic model of B.
View Article and Find Full Text PDFBackground: The somatic mutation theory predicts that cancer risk should scale proportionally with lifetime cell divisions; yet large-bodied and long-lived species exhibit lower-than-expected cancer incidence-a long-standing contradiction termed Peto's paradox. Resolving this paradox and clarifying how tumor mutational burden (TMB) shapes treatment response to immune-checkpoint inhibitor (ICI) therapy remain unmet needs in precision oncology.
Methods: This study analyzed three data streams: (1) human cancer incidence data from North American registries; (2) cancer mortality records for 110,148 mammals (191 species) linked to body mass, life expectancy, and cancer risk, and (3) >30,000 tumors profiled in three independent pan-cancer cohorts and clinical outcomes in >2,700 ICI-treated patients.
Antiviral Res
September 2025
Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, 98101, United States; Department of Pediatrics, University of Washington, Seattle, WA, 98195, United States; Department of Biochemistry, University of Washington, Seattle, WA, 98195, United States. Ele
The burden of dengue on human health has dramatically increased in recent years, underscoring the urgent need for effective therapeutic interventions. Despite decades of research since the discovery of the dengue virus, no specific antiviral treatments are available and strategies to reliably prevent severe disease remain limited. Direct-acting antivirals against dengue are under active investigation but have shown limited efficacy to date.
View Article and Find Full Text PDFJ Immunother Cancer
May 2025
Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA
A tumor's ability to attract innervation is a critical factor in tumor progression and immune escape, with the sympathetic nervous system playing a major role. Catecholamines released by sympathetic nerves activate adrenergic receptors on tumor cells, enhancing growth and resistance to therapies, while activation of adrenergic receptors on immune cells triggers immunosuppressive activity in the tumor microenvironment. Nerve growth factor (NGF) produced by tumor cells is a key driver of tumor innervation, making it a promising target for novel therapeutic strategies.
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