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Scientific discovery has advanced human society in countless ways, but research requires the expenditure of energy and resources. This Scientific Life article details one laboratory's efforts to reduce the environmental impact of wet-lab research and provides a series of resources to improve lab sustainability.
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http://dx.doi.org/10.1016/j.tibs.2022.09.001 | DOI Listing |
Cancer Cell Int
August 2025
Department of Laboratory Medicine, Huashan Hospital, Fudan University, 12 Wulumuqi Middle Road, Shanghai, 200040, China.
Chimeric antigen receptor-modified T cell therapy, originally employed in hematological malignancies treatment, has made significant strides in addressing solid tumors in recent years. Presently, second-generation CAR-T therapy has reached clinical implementation, while fifth-generation CAR-T therapy is in active development. However, initial clinical trials in solid tumors have shown limited success, primarily due to the immunosuppressive microenvironment of the tumor and the scarcity of tumor-specific antigens.
View Article and Find Full Text PDFCurr Opin Organ Transplant
August 2025
Purpose Of Review: Persistent disparities in access to kidney transplantation, particularly living donor transplant and preemptive transplant, have gained increasing national attention including efforts to describe their multifactorial root causes. Multilevel structural impediments occurring at the recipient, donor, clinician, and health system level contribute to these disparities. This review overviews these key barriers, as well as recent successful interventions designed to address longstanding disparities.
View Article and Find Full Text PDFJ Homosex
August 2025
Birmingham Centre for Media and Cultural Research, Birmingham City University, Birmingham, UK.
On July 11, 1992, eighteen years after the Carnation Revolution ended the fascist dictatorship in Portugal, the Portuguese public broadcaster ran a news story about the launch of the first ever gay magazine to reach Portuguese newsstands, one that was written in Portuguese despite still bearing the title of its parent publication, . Five years earlier, on July 13, 1987, however, a petition had been signed at the Homosexual Summer University of Marseille denouncing 's fascist politics. In this article, we offer a critical picture of 's peculiar place in the landscape of late 20-century homosexual media in Europe.
View Article and Find Full Text PDFBr J Haematol
August 2025
Hematology Department, Beijing Key Laboratory of Pediatric Hematology Oncology; National Key Discipline of Pediatrics (Capital Medical University); Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Children's Hospital, National Center for Children's Health, Capital Medical
Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by decreased platelet counts and increased bleeding risk. Although paediatric ITP often resolves spontaneously, some children do not respond to first-line treatments, thus requiring rituximab as a second-line therapy to reduce bleeding risks and corticosteroid exposure. Currently, there is no reliable method to predict the efficacy of rituximab.
View Article and Find Full Text PDFDissemination and implementation (D&I) science is ascendant within public health in the United States, but D&I scientists have long voiced concern at their field's capacity to fulfill two essential and intertwined public health responsibilities: analyzing and intervening in macrosocial determinants and achieving health equity. To help break this impasse, we explore D&I's theoretical roots by critically reviewing three historical eras, eras that D&I's origin story has identified as foundational to D&I's development: 1890-1903: Tarde's Laws of Imitation. 1920-1960: Rural Sociology.
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