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Article Abstract
This study confirmed the effect of sodium/iodine symporter (NIS) expression on existing drugs by in vitro and in vivo tests using cultured cell lines. The tumor growth inhibitory effect of sodium astatide ([At]NaAt) was evaluated by in vitro and in vivo tests using human thyroid cancer cells (K1, K1/NIS and K1/NIS-DOX). NIS expression in cancer cells was controlled using the Tet-On system. [I]NaI was used as control existing drug. From the results of the in vitro studies, the mechanism of [At]NaAt uptake into thyroid cancer cells is mediated by NIS, analogous to [I]NaI, and the cellular uptake rate correlates with the expression level of NIS. [At]NaAt's ability to inhibit colony formation was more than 10 times that of [I]NaI per becquerel (Bq), and [At]NaAt's DNA double-strand breaking (DSB) induction was more than ten times that of [I]NaI per Bq, and [At]NaAt was more than three times more cytotoxic than [I]NaI (at 1000 kBq each). In vivo studies also showed that the tumor growth inhibitory effect of [At]NaAt depended on NIS expression and was more than six times that of [I]NaI per Bq.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9779414 | PMC |
| http://dx.doi.org/10.3390/ijms232415509 | DOI Listing |
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