Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Neoadjuvant immune checkpoint blockade (ICB) prior to surgery may induce early pathological responses in head and neck squamous cell carcinoma (HNSCC) patients. Routine imaging parameters fail to diagnose these responses early on. Magnetic resonance (MR) diffusion-weighted imaging (DWI) has proven to be useful for detecting HNSCC tumor mass after (chemo)radiation therapy.
Methods: 32 patients with stage II-IV, resectable HNSCC, treated at a phase Ib/IIa IMCISION trial (NCT03003637), were retrospectively analyzed using MR-imaging before and after two doses of single agent nivolumab (anti-PD-1) ( = 6) or nivolumab with ipilimumab (anti-CTLA-4) ICB ( = 26). The primary tumors were delineated pre- and post-treatment. A total of 32 features were derived from the delineation and correlated with the tumor regression percentage in the surgical specimen.
Results: MR-DWI data was available for 24 of 32 patients. Smaller baseline tumor diameter ( = 0.01-0.04) and higher sphericity ( = 0.03) were predictive of having a good pathological response to ICB. Post-treatment skewness and the change in skewness between MRIs were negatively correlated with the tumor's regression ( = 0.04, = 0.02).
Conclusion: Pre-treatment DWI tumor diameter and sphericity may be quantitative biomarkers for the prediction of an early pathological response to ICB. Furthermore, our data indicate that ADC skewness could be a marker for individual response evaluation.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776484 | PMC |
| http://dx.doi.org/10.3390/cancers14246235 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Multi-parametric MRI-based radiomics nomogram for predicting lymphovascular space invasion in early-stage cervical adenocarcinoma.
Front Oncol
August 2025
Department of Radiology, Jinshan Hospital, Fudan University, Shanghai, China.
Purpose: To develop a magnetic resonance imaging (MRI)-based radiomics nomogram to predict lymphovascular space invasion (LVSI) status in patients with early-stage cervical adenocarcinoma (CAC).
Methods: Clinicopathological and MRI data from 310 patients with histopathologically confirmed early-stage CAC were retrospectively analyzed. Patients were divided into training (n = 186) and validation (n = 124) cohorts.
Charting the Neurotropism of Human Parvovirus B19 and Encephalitis: A Systematic Review of Existing Literature of 25 Years.
Cureus
August 2025
Neurological Surgery, Punjab Institute of Neurosciences, Lahore, PAK.
Parvovirus B19 (PVB19) is an infrequent, serious, yet treatable cause of infection in immunocompromised hosts. Neurological manifestations of PVB19 are encephalitis, encephalopathy, meningitis, cerebellar ataxia, transverse myelitis, stroke, and peripheral neuropathy. The objective is to identify the exact clinical and diagnostic features specific to parvovirus B19 encephalitis for the isolation and management of the pathology.
View Article and Find Full Text PDFComplete Protocol Administration Reduces Local Recurrence and Residual Tumor in Superselective Intra-arterial Cisplatin Infusion and Concomitant Radiotherapy for Maxillary Sinus Cancer.
Interv Radiol (Higashimatsuyama)
June 2025
Department of Radiology, The Jikei University School of Medicine, Japan.
Purpose: To investigate the risk factors for local maxillary sinus squamous cell carcinoma recurrence/residual tumor after superselective intra-arterial cisplatin infusion and concomitant radiotherapy.
Material And Methods: The protocol of superselective intra-arterial cisplatin infusion and concomitant radiotherapy was as follows: cisplatin was administered once per week for 7 weeks, and the dose of every procedure was 100 mg/m. Radiation was administered during the same period using intensity-modulated radiation therapy, with a total dose of 70 Gy (2 Gy/35 fractions).
MRI-based diffusion weighted imaging and diffusion kurtosis imaging grading of clear cell renal cell carcinoma using a deep learning classifier.
Oncol Lett
November 2025
Department of Radiology, Zibo Central Hospital, Zibo, Shandong 255020, P.R. China.
Clear cell renal cell carcinoma (ccRCC) is a malignant tumor, originating from the renal epithelium, and accounts for ~85% of RCC cases. The present study aimed to validate the efficacy of an MRI deep learning (DL) model to preoperatively predict the pathological grading of ccRCC. Therefore, a DL algorithm was constructed and trained using diffusion weighted imaging (DWI) and diffusion kurtosis imaging (DKI) sequence images.
View Article and Find Full Text PDFReversible Toxic-Metabolic Encephalopathy in Fluroacetamide Intoxication: A Case Report and Review of the Literature.
Int Med Case Rep J
August 2025
Department of Neurology, Chongzhou People's Hospital, Sichuan, People's Republic of China.
Fluoroacetamide, a commonly used convulsant rodenticide, can rapidly damage the nervous, digestive, and cardiovascular systems, potentially leading to fatal outcomes if ingested. This study reports the case of a 62-year-old Chinese woman who presented with symptoms of intoxication, including slurred speech, agitation, and seizure-like episodes, accompanied by gastrointestinal symptoms such as vomiting, skin bruising, and mild liver dysfunction. Toxin analysis revealed the presence of fluoroacetate in her blood and urine, and diffusion weighted imaging (DWI) imaging indicated white matter lesions, leading to the diagnosis of rare fluoroacetamide poisoning.
View Article and Find Full Text PDF