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Waste heat dissipated in the exhaust system of a combustion engine represents a major source of energy to be recovered and converted into useful work. The Waste Heat Recovery System (WHRS) based in an Organic Rankine Cycle (ORC) is an approach for recovering energy from heat sources, achieving a significant reduction in fuel consumption and, as a result, exhaust emissions. This paper studies pressure drop in an ORC shell-and-tubes boiler for a WHRS implementation experimentally and with computational simulations based on a 1-dimensional heat transfer model coupled with 3D calculations. An experimental database is developed, using ethanol in a pressure range of 10-15 absolute bar as working fluid, with mass fluxes inside the tubes in the range of 349.31 kg/s-m and 523.97 kg/s-m, and inlet temperatures in the range of 60 °C and 80 °C. Thus, the friction factor of different regions of the boiler were estimated using both CFD simulations, experimental data, and bibliographic correlations. Simulations of operating points and the results of the experimental test bench showed good agreement in pressure drop results, with a mean absolute error of 15.47%, without a significant increment in the computational cost.
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http://dx.doi.org/10.3390/s22239437 | DOI Listing |
Ophthalmol Glaucoma
September 2025
Department of Ophthalmology and Visual Sciences, University of Michigan W.K. Kellogg Eye Center, Ann Arbor, Michigan. Electronic address:
Purpose: To investigate hand function and eye drop instillation success in adults with and without glaucoma.
Design: Cross-sectional pilot study.
Subjects: Adults aged ≥ 65 years with glaucoma who use eye drops daily and adults aged 65+ without glaucoma who do not regularly use eye drops.
Medicine (Baltimore)
September 2025
Department of Geriatrics, Lianyungang Hospital Affiliated to Jiangsu University, Lianyungang, China.
Cerebral small-vessel disease (CSVD) is an important risk factor for cognitive impairment, which is a pressing health issue for the aging population worldwide. The complex relationship between vascular factors, such as blood pressure variability (BPV) and arteriosclerosis index (AI), and cognitive dysfunction in patients with CSVD is a hot research topic, and research in this area will help prevent and treat cognitive dysfunction in CSVD. This study aims to investigate the effects of diastolic BPV (DBPV) and AI on cognitive function in patients with CSVD.
View Article and Find Full Text PDFInt J Cardiol
September 2025
Department of Biomedical Engineering, University of Cincinnati, Veterans Affairs Medical Center, Cincinnati, OH, USA. Electronic address:
Introduction: Pressure-based fractional flow reserve (FFR) and flow-based coronary flow reserve (CFR) assess the functional status of coronary artery disease (CAD) during cardiac catheterization. Complex hemodynamics may not be adequately explained by either pressure or flow alone. Consequently, pressure-drop coefficient (CDP, the ratio between pressure-drop across a stenosis and distal dynamic pressure) that combines both pressure and flow measurements has been developed to distinguish between epicardial stenosis (ES) and microvascular disease (MVD).
View Article and Find Full Text PDFClin Auton Res
September 2025
Faculty of Medicine, Department of Medicine, Ageing and Age-Associated Disorders Research Group, Division of Geriatric Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Background: Orthostatic hypotension (OH) is prevalent in older adults and is often associated with falls. However, the presence or absence of symptoms in OH may be mediated by cerebral autoregulation, which helps maintain cerebral perfusion during blood pressure fluctuations.
Methods: We recruited 40 older adults (aged ≥ 55 years) from the Malaysian Elders Longitudinal Research (MELoR) cohort.
Int J Numer Method Biomed Eng
September 2025
Department of Chemical System Engineering, School of Engineering, The University of Tokyo, Tokyo, Japan.
The effect of shape and size of embolic agents on embolization phenomena has been discussed clinically for transcatheter arterial chemoembolization (TACE). We numerically discussed the unique embolization behavior of new deformable toroidal microparticles in blood vessels by computational fluid dynamics simulations. We employed an Eulerian-Eulerian (full Eulerian) fluid-structure interaction (FSI) method to analyze the flow and deformation behaviors of a deformable torus in a cylindrical pipe.
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