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Article Abstract
Metal-organic frameworks (MOFs) can be used as reservoirs of metal ions with relevant antibacterial effects. Here, two novel Zn-based MOFs with the formulas [Zn(μ-O)(μ-FA)L] (GR-MOF-8) and [Zn(μ-O)L(HO)] (GR-MOF-9) (HL: 5-((4-carboxyphenyl)ethynyl) in isophthalic acid and FA (formate anion) were solvothermally synthetized and fully characterized. The antibacterial activity of GR-MOF-8 and 9 was investigated against (SA) and () by the agar diffusion method. Both bacteria are among the most relevant human and animal pathogens, causing a wide variety of infections, and are often related with the development of antimicrobial resistances. While both Zn-based materials exhibited antibacterial activity against both strains, GR-MOF-8 showed the highest inhibitory action, likely due to a more progressive Zn release under the tested experimental conditions. This is particularly evidenced in the inhibition of , with an increasing effect of GR-MOF-8 with time, which is of great significance to ensure the disappearance of the microorganism.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736432 | PMC |
| http://dx.doi.org/10.3390/nano12234139 | DOI Listing |
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