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| http://dx.doi.org/10.1016/j.bone.2022.116641 | DOI Listing |
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Association of obesity and adrenal androgen levels with bone age progression in boys with premature adrenarche.
Ann Pediatr Endocrinol Metab
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Department of Pediatrics, Hanyang University Hospital, Seoul, Korea.
Purpose: Both premature adrenarche (PA) and obesity are closely linked to increases in bone age (BA). However, the mechanisms underlying these associations are unclear as research data, particularly in boys, are lacking. Therefore, our aim in this study was to test for an association between obesity and BA progression in boys with PA and to assess the role of adrenal androgen in the mediation of any identified association.
View Article and Find Full Text PDFFractures are Highly Correlated with Bone Density and Inversely Correlated with Bone Turnover Markers in Autosomal Dominant Osteopetrosis.
J Bone Miner Res
September 2025
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States.
Autosomal Dominant Osteopetrosis (ADO) is a rare, osteosclerotic disorder usually caused by missense variants in the CLCN7 gene, resulting in impaired osteoclastic bone resorption. Penetrance is incomplete and disease severity varies widely, even among relatives within the same family. Although ADO can cause visual loss, osteonecrosis, osteomyelitis, and bone marrow failure, the most common complication of ADO is fracture.
View Article and Find Full Text PDFHeight, weight, and body mass index trajectories and their correlation with functional outcome assessments in boys with Duchenne muscular dystrophy.
Dev Med Child Neurol
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John Walton Muscular Dystrophy Research Centre, Clinical and Translational Research Institute, Newcastle University and Newcastle Hospitals NHS Foundation Trusts, Newcastle upon Tyne, UK.
Aim: To examine the factors influencing height, weight, and body mass index (BMI) z-scores, and the relationship between them and motor performance, in boys with Duchenne muscular dystrophy (DMD).
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Serum Osteocalcin in Pediatric Osteogenesis Imperfecta: Impact of Disease Type and Bisphosphonate Therapy.
Int J Mol Sci
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Department of Pediatrics, Neonatal Pathology and Metabolic Bone Diseases, Medical University of Lodz, Sporna 36/50, 91-738 Lodz, Poland.
The aim of this study was to analyze the factors that may influence serum osteocalcin levels in children with osteogenesis imperfecta treated with intravenous sodium pamidronate and to define the role of osteocalcin assessment. The study included 61 patients diagnosed with osteogenesis imperfecta type 1 or 3, aged 2 to 18, hospitalized for intravenous sodium pamidronate administration. A retrospective analysis of medical records was conducted, collecting information on age, sex, body weight, height, the number of long bone fractures throughout life, serum levels of osteocalcin, creatinine, alkaline phosphatase, 25(OH)D, and DXA BMD z-scores for the L1-L4 spine segment.
View Article and Find Full Text PDFExploring the natural history of bone mineral density in Duchenne muscular dystrophy: a systematic literature review.
Osteoporos Int
August 2025
Department of Pediatrics, Division of Endocrinology and Metabolism, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, Canada.
Purpose: In Duchenne muscular dystrophy (DMD) osteoporosis and fragility fractures present significant comorbidities, resulting from progressive myopathy reduced weight-bearing and osteotoxic effects of prolonged glucocorticoid (GC) use. This systematic literature review (SLR) assessed the natural course of bone mineral density (BMD) in individuals with DMD and the factors associated with its natural progression.
Methods: A systematic literature review was conducted to evaluate BMD in individuals with DMD.