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Background: Studies on facial hyperpigmentation across different facial units are limiting. We aimed to analyze melanin pigmentation images to observe facial pigmentary demarcation lines (FPDLs) and suggest facial hyperpigmentation types for normal individuals.
Materials And Methods: 3D facial melanin pigmentation images of 173 volunteers were obtained and analyzed for the presence of FPDLs. Pigmentation severity was assessed for each of the thirteen facial pigment units. The images were then grouped according to a pattern of hyperpigmentation to suggest three facial hyperpigmentation types-dark spot, photoaging and post-inflammatory hyperpigmentation.
Results: Four groups of FPDLs including a novel group I were observed. Nasal, frontal, auricular were the darkest pigmented facial pigment unit, and the anterior neck was the least pigmented. The dark spot type was the most common facial hyperpigmentation type. The photoaging type and the PIH type showed age-dependent distribution, as the photoaging type was more common among the subjects over 40s, and the PIH type was more common in younger subjects.
Conclusion: Facial hyperpigmentation among healthy individuals with Fitzpatrick skin types II-IV is often accompanied by FPDLs and categorized into three types. Each type is modeled after the pattern of pigmentation associated with certain dermatological disorders. The practical implications of facial hyperpigmentation types can be resourceful in various fields including prevention and treatment of pigmentary disorders.
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http://dx.doi.org/10.1111/srt.13251 | DOI Listing |
Adv Healthc Mater
September 2025
National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou, 215123, China.
Melasma is a facial hyperpigmentation disease that significantly impacts patients' quality of life. Clinical treatment is limited by the short half-lives and hydrophilicity of drugs, necessitating release curve optimization to maintain a stable therapeutic concentration for an extended period. This article utilizes natural biomaterials to design a core-shell structured microneedle, combining the "immediate release" and "delayed release" module to achieve programmed drug release.
View Article and Find Full Text PDFJ Diabetes Metab Disord
December 2025
Evidence Based Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Non-islet cell tumor hypoglycemia (NICTH) is a rare paraneoplastic syndrome resulting from excessive secretion of pro-insulin-like growth factor 2 (proIGF-2). This leads to hypoinsulinemic hypoglycemia and, in some cases, acromegaly. We report the case of a 52-year-old woman with NICTH syndrome who had decreased levels of insulin-like growth factor 1 (IGF1), insulin, C-peptide, and growth hormone (GH).
View Article and Find Full Text PDFJ Drugs Dermatol
September 2025
The accumulation of endogenous advanced glycation end products (AGEs) has been shown to degrade the integrity of the extracellular matrix in the dermis, resulting in signs of aging. Resurfacing procedures are a first-line treatment option. Post-procedure skin care is integral in achieving optimal results with minimal downtime.
View Article and Find Full Text PDFClin Cosmet Investig Dermatol
August 2025
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia.
Post-acne erythema (PAE) is persistent erythema after acne vulgaris (AV) inflammatory lesions have resolved. Pulsed dye laser (PDL) is the gold standard for vascular lesions and is effective for PAE. Tranexamic acid (TA) can reduce vascular endothelial growth, angiogenesis, and inflammation by inhibiting plasminogen activity, and can be used in PAE treatment.
View Article and Find Full Text PDFCureus
July 2025
Dermatology, King Abdulaziz Medical City, Jeddah, SAU.
We describe a 52-year-old Saudi male who presented with a six-month history of an enlarging pigmented macule over the left forehead. Clinical examination revealed a 1.4 × 2 cm asymptomatic black-grey patch with irregular borders and variable pigmentation.
View Article and Find Full Text PDF