98%
921
2 minutes
20
Introduction: Lead dwell time >10 years is a recognized predictor for transvenous lead extraction (TLE) failure and complications. Data on the efficacy and safety of TLE using the bidirectional rotational mechanical sheaths in patients with very old leads are lacking. In this multicenter study, we reported the outcomes of transvenous rotational mechanical lead extraction in patients with leads implanted for ≥10 years.
Methods: A total of 441 leads (median: 159 months [135-197]; range: 120-487) in 189 consecutive patients were removed with the Evolution RL sheaths (Cook Medical, Bloomingtom, IN, USA) and mechanical ancillary tools supporting the procedures.
Results: The main indication for TLE was infection in 74% of cases. Complete procedural success rate, clinical success rate, per lead were 94.8% and 98.2%, respectively. Failure of lead extraction was seen in 1.8% of leads. The additional use of a snare via the femoral approach was required in 9% of patients. Lead dwell time was the only predictor of incomplete led removal (odds ratio: 1.009; 95% confidence interval [CI]: 1.003-1.014; p = .002). Four major complication (2%) were encountered. During a mean time follow-up of 31 ± 27 months, 21 patients (11%) died. No procedure-related mortality occurred. Predictors of mortality included severe left ventricular systolic dysfunction (hazard ratio [HR]: 8.06; 95% CI: 2.99-21.73; p = .001), TLE for infection (HR: 8.0; 95% CI: 1.04-62.5; p = .045), diabetes (HR: 3.7; 95% CI: 1.48-9.5; p = .005), and previous systemic infection (HR: 3.1; 95% CI: 1.17-8.24; p = .022). Incomplete lead removal or failure lead extraction did not impact on survival during follow-up.
Conclusion: Our findings demonstrated that the use of bidirectional rotational TLE mechanical sheaths combined with different mechanical tools and femoral approach allows reasonable success and safety in patients with very old leads at experienced specialized centers.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1111/jce.15767 | DOI Listing |
J Assist Reprod Genet
September 2025
UFR-SVS, UVSQ, 78180, Montigny Le Bretonneux, France.
Introduction: Complex chromosomal rearrangements (CCRs) are frequently associated with infertility and have been described in the literature. Chromoanagenesis corresponds to a group of CCRs with a high number of chromosome breakpoints. These CCRs involving small structural variations can only be identified by using high-resolution genomic techniques.
View Article and Find Full Text PDFJ Imaging Inform Med
September 2025
Department of Diagnostic, Interventional and Pediatric Radiology (DIPR), Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
Large language models (LLMs) have been successfully used for data extraction from free-text radiology reports. Most current studies were conducted with LLMs accessed via an application programming interface (API). We evaluated the feasibility of using open-source LLMs, deployed on limited local hardware resources for data extraction from free-text mammography reports, using a common data element (CDE)-based structure.
View Article and Find Full Text PDFEnviron Monit Assess
September 2025
College of Ecological and Environmental Engineering, Guizhou Minzu University, Guiyang, 550025, China.
The rapid development of industry and agriculture has led to a significant increase in the toxicity and pollution of cadmium (Cd) and lead (Pb) in soil. Consequently, soil remediation employing biochar or modified biochar has emerged as a cost-effective and environmentally sustainable approach to address the issue of heavy metal (HM) ion pollution. PEI-functionalization biochar (PBC) derived from corn straw (PBCC), wood straw (PBCW), and rice straw (PBCR) was synthesized to immobilize Cd and Pb in contaminated acidic yellow soil.
View Article and Find Full Text PDFHeart Rhythm
September 2025
Cardiac Electrophysiology Section, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio. Electronic address:
Background: Transvenous lead extraction (TLE) is increasingly performed in older adults, but literature has reported divergent outcomes in very old populations.
Objective: To investigate the impact of patient age on TLE outcomes, with an emphasis on older patients.
Methods: Using the ExTRACT registry, the largest TLE registry to date, we analyzed 5,090 patients who underwent TLE between August 1996-2022 at the Cleveland Clinic, a high-volume center.
J Hazard Mater
September 2025
State Key Laboratory of Environmental Criteria and Risk Assessment, and State Environmental Protection Key Laboratory of Simulation and Control of Groundwater Pollution, Chinese Research Academy of Environmental Sciences, Beijing 100012, China. Electronic address:
While humic acids (HAs) are known to modulate heavy metal behavior, their profound heterogeneity across soil aggregate fractions remains overlooked. Crucially, whether HA origin within distinct soil aggregates differentially governs heavy metal speciation and bioavailability is unknown-creating a critical knowledge gap for targeted soil remediation. This study deciphers, for the first time, how aggregate-specific HAs control cadmium (Cd) and lead (Pb) dynamics.
View Article and Find Full Text PDF