Insight into the structural dynamics of light sensitive proteins from time-resolved crystallography and quantum chemical calculations.

Curr Opin Struct Biol

Department of Chemistry, Lomonosov Moscow State University, Moscow 119991, Russia; Max-Planck-Institut für medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany. Electronic address:

Published: December 2022


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Article Abstract

The structural dynamics underlying molecular mechanisms of light-sensitive proteins can be studied by a variety of experimental and computational biophysical techniques. Here we review recent progress in combining time-resolved crystallography at X-ray free electron lasers and quantum chemical calculations to study structural changes in photoenzymes, photosynthetic proteins, photoreceptors, and photoswitchable fluorescent proteins following photoexcitation.

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http://dx.doi.org/10.1016/j.sbi.2022.102496DOI Listing

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