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Patch test helps in identifying the allergen causing allergic contact dermatitis. Proper identification of the site of individual patch test allergen is very important for identifying the positive allergen. In this article, various techniques for markings patch test sites are discussed.
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http://dx.doi.org/10.25259/IJDVL_948_2021 | DOI Listing |
Adv Pharm Bull
July 2025
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal- 576104, India.
Purpose: The present study aimed to fabricate microneedles (MNs) for transdermal delivery of insulin. Chitosan-conjugated carboxy phenyl boronic acid polymer was synthesized and characterized to load insulin in the form of nanoparticles.
Methods: Optimized insulin nanoparticles (ILN-NPs) were loaded into MN arrays by micromolding, and the resulting MN patches were characterized by scanning electron microscopy (SEM) and mechanical failure tests.
Contact Dermatitis
September 2025
Immuno-Allergology Clinic, CHU Brugmann, ULB, Brussels, Belgium.
Dermatitis
September 2025
From the Department of Dermatology, Venereology and Leprology, All India Institute of Medical Sciences (AIIMS), Bhopal, India.
Contact dermatitis (CD), which includes both allergic CD and irritant CD, is a common inflammatory condition that can pose significant diagnostic challenges. Although patch testing is the gold standard for identifying causative allergens for allergic contact dermatitis (ACD), it is time-consuming, subjective, and requires expert interpretation. Recent advancements in artificial intelligence (AI), particularly in machine learning (ML) and deep learning, have shown promise in improving the accuracy, efficiency, and accessibility of CD diagnosis and management.
View Article and Find Full Text PDFBiomater Adv
September 2025
Department of Applied Science and Technology (DISAT), Politecnico di Torino, Corso Duca Degli Abruzzi 24, 10129 Torino, Italy.
Tailoring surface characteristics is key to guiding scaffold interaction with the biological environment, promoting successful biointegration while minimizing immune responses and inflammation. In cardiac tissue engineering, polyvinylidene fluoride (PVDF) is a material of choice for its intrinsic piezoelectric properties, which can be enhanced through electrospinning, also enabling the fabrication of nanofibrous structures mimicking native tissue. However, the inherent hydrophobicity of PVDF can hinder its integration with biological tissues.
View Article and Find Full Text PDFJACC Case Rep
September 2025
Lee Health Heart Institute, Fort Myers, Florida, USA. Electronic address:
Transcatheter aortic valve replacement (TAVR) is a preferred treatment option for many patients with severe aortic stenosis, but concerns exist regarding safety in patients with nickel allergy due to metallic valve frames. We report a series of 7 patients with a history of nickel allergy who underwent TAVR. Preprocedural allergy evaluation varied, including patch testing or direct skin contact with valve fragments.
View Article and Find Full Text PDF