Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Acetylcholine (ACh) signaling is critical for central nervous function and is known to be abnormal in schizophrenia (SZ), a chronic neuropsychiatric disorder in which cognitive deficits persist, despite treatment. This review provides a summary of the clinical evidence linking ACh abnormalities to SZ-associated cognitive deficits, an overview of ACh-based pro-cognitive strategies attempted in SZ, and a survey of recent studies that describe the impact of anticholinergic medication burden on cognitive outcomes in SZ. Methodological challenges that currently limit more substantial investigation of ACh in SZ patients and future directions are also discussed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/7854_2022_400 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Incidence and risk factors for postoperative urinary retention in older patients with hip fracture: a scoping review.
BMJ Open
September 2025
Department of Nursing, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China
Objectives: This scoping review aimed to synthesise the currently available evidence and influencing factors on the occurrence of postoperative urinary retention (POUR) in older patients with hip fractures.
Design: This scoping review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews guideline.
Data Sources: PubMed, Cochrane Library, CINAHL, Web of Science, Chinese National Knowledge Infrastructure, Wanfang Data and Sinomed databases were systematically searched from database inception to 1 September 2024.
Real-World Claims Analysis to Characterize the Burden of Tardive Dyskinesia in Long-Term Care Settings.
Neurol Ther
September 2025
Dayton Psychiatric Associations, Dayton, OH, USA.
Introduction: Tardive dyskinesia (TD), a persistent and often debilitating movement disorder, is associated with prolonged exposure to dopamine receptor-blocking agents. Individuals aged ≥ 60 years are at increased risk for TD and TD-related burden (e.g.
View Article and Find Full Text PDFAnticholinergic burden and polypharmacy in patients referred from primary care to tertiary dementia centers in Brazil.
Dement Neuropsychol
August 2025
Hospital Santa Marcelina, São Paulo SP, Brazil.
Unlabelled: Anticholinergic burden (ACB) and polypharmacy are poorly studied in the context of primary care in Brazil.
Objective: To evaluate the ACB and polypharmacy of individuals with suspected dementia referred from primary care to tertiary dementia outpatient clinics in Brazil.
Methods: We performed a cross-sectional study in two tertiary dementia clinics.
[Efficacy and influencing factors of preoperative pharmacological mydriasis in type 2 diabetic patients undergoing cataract surgery].
Zhonghua Yi Xue Za Zhi
September 2025
Ophthalmology Center, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China.
To investigate the efficacy and influencing factors of pharmacological mydriasis in type 2 diabetic patients undergoing cataract surgery. The study used a single-arm clinical trial design. Patients with type 2 diabetes who underdoing cataract surgery in the Second Affiliated Hospital, Zhejiang University School of Medicine from April to July 2024 were selected using convenience sampling method.
View Article and Find Full Text PDFXanomeline-trospium: defining its place among the current antipsychotic landscape.
Acta Neuropsychiatr
September 2025
Kent and Medway NHS Partnership Trust, Maidstone, UK.
Progress in the development of new and improved medications for psychosis has been notably slow and disappointing. The first treatment for schizophrenia was introduced in early 1950s and the majority of medications available today exclusively function through dopamine antagonism. The search for a new drug treatment with a different mechanism of action was extremely slow-paced mainly due to the limited understanding of the aetiology, pathophysiology and genetics of schizophrenia.
View Article and Find Full Text PDF