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In order to develop a new kind of filament material for the fused deposition modeling (FDM) 3D printing, the residue of Astragalus (ROA), one of the most important Chinese herbal medicines, and polylactic acid were chosen as the raw materials to FDM 3D print biomass composite specimens, the effects of the printing parameters on the properties of the specimens were investigated. The results indicated that the mechanical properties and thermal stability of the printed specimen were affected obviously by the parameters while the melting and crystallization behavior of the specimens were little affected. For the wettability, it was also little affected by the printing parameter except for the printing speed. Increasing the printing temperature and the filling density or reducing the printing speed and the layer thickness could improve both the mechanical properties and the thermal stability of the FDM 3D printed PLA/ROA composite specimen; reducing the deposition angle could also improve the mechanical properties while having little effect on the thermal stability of the specimen.
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http://dx.doi.org/10.3390/molecules27217373 | DOI Listing |
Regen Biomater
August 2025
Institute of Stomatology & Oral Maxilla Facial Key Laboratory, First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.
Reconstructing bone defects remains a significant challenge in clinical practice, driving the urgent need for advanced artificial grafts that simultaneously promote vascularization and osteogenesis. Addressing the critical trade-off between achieving high porosity/strength and effective bioactivity at safe ion doses, we incorporated strontium (Sr) into β-tricalcium phosphate (β-TCP) scaffolds with a triply periodic minimal surface (TPMS) structure using digital light processing (DLP)-based three-dimensional (3D) printing. Systematically screening Sr concentrations (0-10 mol%), we identified 10 mol% as optimal, leveraging the synergy between the biomimetic TPMS architecture, providing exceptional mechanical strength (up to 1.
View Article and Find Full Text PDFInt J Pharm X
June 2025
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, China.
Ultra-sensitive pH-responsive drug delivery system designed to operate within the slightly acidic microenvironment of tumors are highly desired for hydrogel applications in cancer therapy. In this study, 4-Formylbenzoic acid modified polyvinyl alcohol (PVA-FBA, PF) was synthesized and utilized as a carrier for encapsulating the anticancer drug Doxorubicin (Dox). This was subsequently crosslinked with polyethylenimine (PEI) via benzoic-imine bond to form drug-loaded PVA-FBA/PEI hydrogel (D-PFP).
View Article and Find Full Text PDFBiochem Biophys Rep
December 2025
Department of Neurosurgery, Faculty of Medicine and University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany.
Brillouin microscopy allows mechanical investigations of biological materials at the subcellular level and can be integrated with Raman spectroscopy for simultaneous chemical mapping, thus enabling a more comprehensive interpretation of biomechanics. The present study investigates different in vitro glioblastoma models using a combination of Brillouin and Raman microspectroscopy. Spheroids of the U87-MG cell line and two patient-derived cell lines as well as patient-derived organoids were used.
View Article and Find Full Text PDFJ Oral Biol Craniofac Res
August 2025
Department of Prosthodontics and Crown & Bridge, SRM Dental College, Ramapuram Campus, SRM Institute of Science and Technology, Chennai, Tamil Nadu, India.
Background Of The Study: known for its bioactive phytochemicals and antimicrobial potential; however, studies evaluating its outcome on the color, mechanical properties and antimicrobial activity of 3D-printed provisional dental resins are lacking. So this study evaluate the effect of seed extract incorporation on the color assessment, flexural strength, compressive strength, microhardness and antimicrobial activity of 3D-printed provisional crown and bridge resin.
Materials And Methods: A total of 240 samples were prepared, with 60 samples allocated to four groups based on 0 %, 1.
RSC Adv
September 2025
Computational Biotechnology, RWTH Aachen University Worringerweg 3 52074 Aachen Germany
Recent advances in two-dimensional (2D) magnetic materials have promoted significant progress in low-dimensional magnetism and its technological applications. Among them, atomically thin chromium trihalides (CrX with X = Cl, Br, and I) are among the most studied 2D magnets due to their unique magnetic properties. In this work, we employ density functional theory calculations to investigate the mechanical and electronic properties of CrX monolayers in the presence of in-plane uniaxial strain.
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