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Aim: To review the evidence for the effects of adapted bicycle riding on body structures and functions, activity, participation, and quality of life outcomes in children with disabilities, along with family-level participation outcomes.
Method: A systematic review with searches of nine electronic databases to identify studies involving participants with a developmental disability aged 4 to 18 years who used a dynamic adapted bicycle was completed in August 2021. Risk of bias was assessed based on individual study designs. A narrative synthesis integrated the findings of the included studies. Certainty of evidence was synthesized using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.
Results: Ten studies were included with 234 participants. Five studies reported outcomes at the body structures and functions level, ten reported activity-level outcomes, two reported participation-related outcomes, and none assessed quality of life or family participation in social and recreational activities.
Interpretation: Adapted bicycle riding interventions may improve gross motor function, enhance lower-limb muscle strength, and promote physical activity; however, certainty of evidence of effects was rated very low using GRADE. Further research is required to understand the impact of adapted bicycle riding on the participation outcomes of children and adolescents with disabilities and on family-level participation in social and recreational activities.
What This Paper Adds: Adapted bicycle riding interventions may improve motor functions and physical activity. Evidence about participation outcomes after adapted bicycle riding is limited. Research on adapted bicycle riding interventions in natural settings is needed.
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http://dx.doi.org/10.1111/dmcn.15446 | DOI Listing |
Nat Rev Clin Oncol
August 2025
Department of Medical Oncology, Gustave Roussy, Villejuif, France.
The treatment landscape of non-small-cell lung cancer (NSCLC) has evolved considerably with the integration of immune-checkpoint inhibitors (ICIs) into first-line regimens. However, the majority of patients will ultimately have primary resistance or develop secondary resistance, driven by a complex interplay of intrinsic tumour biology and adaptive changes within the tumour microenvironment (TME), which can be further amplified by host-related factors such as dysbiosis and organ-specific conditions. Despite these heterogeneous origins, most mechanisms of resistance to ICIs lead to an immunosuppressive TME as the final common pathway.
View Article and Find Full Text PDFAdv Physiol Educ
August 2025
Department of Physiology, College of Osteopathic Medicine, Michigan State University, East Lansing MI.
Blood pressure regulation keeps us alive, yet its underlying mechanisms often remain abstract for students. Heart rate, stroke volume, vascular resistance, and compliance interact continuously to shape arterial pressure-but in many classrooms, these variables feel disconnected from observable outcomes. To bridge this gap, we developed a simple, low-cost analog model that allows learners to manipulate key cardiovascular parameters and immediately observe the results.
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August 2025
Dalian University College of Physical Education, Dalian University, Dalian, Liaoning, China.
Objectives: This study examines the effects of a 4-week high-intensity interval training (HIIT) program on energy metabolism and maximal oxygen uptake (VOmax) in elite swimmers, aiming to provide empirical evidence for optimizing competitive swimming training.
Methods: Twenty-four competitive swimmers were randomly assigned to either an HIIT experimental group or a control group. The experimental group underwent a structured 4-week lower-limb HIIT program, while the control group continued their regular training regimen.
Int J Inj Contr Saf Promot
July 2025
Applied Economics & Management Research Group, Universidad de Sevilla, Sevilla, Spain.
The promotion of cycling as one of the most popular measures to drive sustainable urban mobility, and the rise in bicycle usage have triggered a debate on the consequences of the coexistence of different transportation modes. This interaction process has been developed rapidly in countries like Spain, where cycling has been fast-tracked. This paper analyzes the safety effect of coexistence in terms of urban traffic accidents.
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August 2025
Laboratory C3S, University Marie & Louis Pasteur, Besançon, France.
"Living High-Training Low and High" (LHTLH) is an altitude/hypoxic training method used to improve physical performance at sea level. The aim of this exploratory study was to investigate the effects of LHTLH on sleep, heart rate variability (HRV), and psychological stress in 10 elite/international level female cyclists (mean age: 17.3 ± 1.
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