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http://dx.doi.org/10.1021/acs.nanolett.2c04109 | DOI Listing |
Sci Rep
September 2025
Department of obstetrics and gynecology, The First Hospital of Lanzhou University, Key Laboratory for GynecologicOncology, Gansu Province, China.
Crit Rev Oncol Hematol
September 2025
Student Research Committee, Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.. Electronic address:
Epigenetic regulation is fundamental to hematopoiesis, influencing stem cell fate, lineage commitment, and the development of hematologic diseases. Recent technological innovations have transitioned from traditional genetic editing towards programmable, reversible epigenetic modulation without altering the DNA sequence. This review explores the evolution of epigenetic editing platforms, from zinc finger proteins and TALEs to the transformative CRISPR-dCas9 system, and introduces next-generation technologies leveraging dCas12, dCas13, and modular RNA-guided systems.
View Article and Find Full Text PDFJ Phys Chem C Nanomater Interfaces
August 2025
Cardiff Catalysis Institute, School of Chemistry, Translational Research Hub, Cardiff University, Maindy Road, Cardiff CF24 4HF, U.K.
Controlling the formation of electron polarons in TiO doped with transition metals is important for the design of transparent conducting oxides for high-efficiency photovoltaics and photocatalysts with tunable reaction selectivities. In this work, EPR spectroscopy is combined with Hubbard-corrected density functional theory (DFT+), with refined atomic-like Hubbard projectors, to show the sensitivity of charge compensation in substitutionally doped Nb-TiO and W-TiO with respect to the TiO polymorph (, anatase or rutile). Both EPR magnetic tensors and DFT+predicted Nb 4 and W 5 orbital occupancies show the formation of differing dopant charge states depending on the TiO polymorph, with nonmagnetic Nb and W in doped anatase and paramagnetic Nb and W in doped rutile.
View Article and Find Full Text PDFAnal Methods
September 2025
Shenzhen Key Laboratory for Nano-Biosensing Technology, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen 518060, China.
Self-assembly is regarded as a facile method to fabricate luminescent nanomaterials with aggregation induced emission (AIE) properties for optical sensor design. In this work, a pH-controlled self-ratiometric sensing platform utilizing aggregation-induced emission (AIE)-active Au(I)-TCEP-Cd(II) nanoaggregates was developed for highly reliable D-penicillamine (DPA) detection. Through stoichiometric coordination with Cd, oligomeric Au(I)-tris(2-carboxyethyl)phosphine (TCEP) complexes could self-assemble into snowflake-like nanoaggregates (∼100 nm) with strong yellow emission (540 nm) and excellent aqueous stability.
View Article and Find Full Text PDFCurr Biol
August 2025
Institute of Cell Biology, Center for Molecular Biology of Inflammation, University of Muenster, 48149 Muenster, Germany; Max Planck Institute for Molecular Biomedicine, 48149 Muenster, Germany. Electronic address:
Directed migration of single cells is central to a large number of processes in development and adult life. Corrections to the migration path of cells are often characterized by periodic loss of polarity that is followed by the generation of a new leading edge in response to guidance cues, a behavior termed "run and tumble." While this phenomenon is essential for accurate arrival at migration targets, the precise molecular mechanisms responsible for the periodic changes in cell polarity are unknown.
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