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http://dx.doi.org/10.1186/s13054-022-04147-1 | DOI Listing |
Nurs Open
September 2025
School of Nursing and Midwifery, Edith Cowan University, Joondalup, Western Australia, Australia.
Background: Interpretive descriptive design is a well-established methodology in healthcare research, offering novel insights into complex phenomena that may elude other qualitative methods. Although interpretive descriptive is effective in translating findings into clinical practice, its application to intensive care unit interventions remains limited. The intricate nature of the intensive care unit environment and the vulnerability of this patient group, necessitates methodologies that delve deeply into interactions and translate them into practical solutions.
View Article and Find Full Text PDFIntensive Care Med Exp
September 2025
Neurosciences Intensive Care Unit, John Radcliffe Hospital, Oxford, UK.
Delirium is a frequent and serious complication of critical illness, yet its pathophysiological mechanisms remain incompletely understood. Serum biomarkers offer a potential avenue for improved diagnosis, risk stratification, and mechanistic insight. This systematic review synthesises evidence from 28 studies evaluating 54 serum biomarkers in relation to delirium among critically ill adult patients.
View Article and Find Full Text PDFJ Clin Anesth
August 2025
School of Clinical Medicine, Southwest Medical University, Luzhou 646000, China; Department of Anesthesiology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu 610072, China. Electronic address:
Introduction: Postoperative hypotension (POH) represents an independent predictor of multiorgan morbidity. Emerging evidence indicates its risks exceed those associated with intraoperative hypotension (IOH). Considering the ubiquitous presence of this pathophysiological disturbance across surgical settings, our meta-analysis evaluates associations between POH and major adverse outcomes.
View Article and Find Full Text PDFMedicina (Kaunas)
August 2025
Department of Anesthesiology and Reanimation, Faculty of Medicine, Cukurova University, 01330 Adana, Turkey.
: Diabetes is a known risk factor for postoperative delirium (POD); however, the relationship between the markers of glycemic control and the occurrence of POD in noncardiac surgery is not established. We initiated this pilot study to determine any possible associations between preoperative HbA1c levels and POD development; this will allow for larger, definitive studies to be designed and preliminary effect sizes to be established for future research. : This retrospective pilot study included 78 patients with diabetes who underwent elective noncardiac surgery under general anesthesia between July 2020 and January 2021.
View Article and Find Full Text PDFBrain Sci
August 2025
Department and Clinic of Adult Psychiatry, Faculty of Medical Sciences, Medical University of Silesia, Ziolowa 45, 40-635 Katowice, Poland.
Background and aim of this review: The ongoing opioid epidemic underscores the urgent need for innovative pharmacological and behavioral interventions to mitigate the impact of opioid use disorder (OUD). This review aims to explore theoretical overlaps between the neurobiological mechanisms underlying OUD development and the pharmacodynamic profile of methylphenidate (MPH). Particular attention is given to the potential shared molecular targets, safety considerations, and therapeutic implications of MPH use in this clinical context.
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