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http://dx.doi.org/10.1136/archdischild-2022-324140 | DOI Listing |
J Clin Endocrinol Metab
August 2025
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant hereditary disorder in which patients develop multiple endocrine tumors simultaneously. Among these, primary hyperparathyroidism (PHPT) is the most common and often the earliest manifestation. All patients with MEN1 and hypercalcemia should have surgery, with most patients requiring surgical treatment before the age of 50.
View Article and Find Full Text PDFBMC Biol
August 2025
Department of Oral and Maxillofacial Surgery, Fujian Medical University Union Hospital, Fuzhou, China.
Background: The cranial base develops from multipotent mesenchymal cells through endochondral ossification. Genetic ablation of Sonic hedgehog (Shh) or Smoothened (Smo) leads to early apoptosis of cranial base cells, thus limiting the study of their role in the early development of cranial base. Our previous studies have shown that administration of 150 mg/kg Vismodegib (a Smo-specific small molecule antagonist) in E9.
View Article and Find Full Text PDFCase Rep Womens Health
October 2025
Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Cervical endometriosis is a rare benign condition characterized by ectopic endometrial glands and stroma within the cervix. Its clinical and imaging features resemble those of cervical adenocarcinoma, making preoperative diagnosis difficult. This report concerns the case of a 41-year-old woman who presented with abnormal genital bleeding.
View Article and Find Full Text PDFCirculation
August 2025
Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials
Background: Myocardial infarction (MI) is a high-prevalence disease that threatens human survival and quality of life worldwide. Considerable evidence has suggested that periodontitis (PD) is detrimental to MI. However, the direct impact of PD on MI is unclear; which oral pathobionts contribute to and how microbial signals regulate the pathogenesis of MI remain obscure.
View Article and Find Full Text PDFCureus
July 2025
Department of Otorhinolaryngology and Head and Neck Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, JPN.
Actinomycosis rarely occurs in the sinonasal region. Here, we report a case of sinonasal actinomycosis associated with an odontogenic cyst of ectopic dental origin. A 28-year-old female patient was referred to our department with a complaint of left buccal pain.
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