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This review describes the state of the art in the field of poly (lactic acid) (PLA)-based materials activated by natural compounds and extracts (active ingredients, AIs) from plant sources for food and biomedical applications. With a multidisciplinary approach, after a description of the synthesis and properties of PLA, special attention was paid to the chemical properties and unconventional extraction technologies of AIs used for PLA activation. Innovative techniques for the incorporation of AIs into PLA; characterization and the antioxidant and antimicrobial properties of the novel materials were discussed. In view of future perspectives, this study has evidenced that some aspects need to be further investigated from joint research between academia and industry, according to the green chemistry principles and circular economy strategy.
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http://dx.doi.org/10.3390/antiox11102074 | DOI Listing |
Crit Rev Toxicol
September 2025
Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands.
There is a concern on the safety of cosmetic ingredients and their endocrine-disrupting (ED) potential. Frequent use as well as the use of a diverse range of cosmetics pose a concern for a potential health risk via aggregate exposure to endocrine disrupting chemicals (EDCs). In this study, a list of ingredients available in cosmetic products that were recently introduced to the Dutch market was retrieved from the commercially accessible Mintel database and screened for the presence of EDCs.
View Article and Find Full Text PDFBiomed Chromatogr
October 2025
College of Food Science and Pharmaceutical Engineering, Zaozhuang University, Zaozhuang, China.
To evaluate the quality of pomegranate peels from different cultivars, pomegranate peel samples from 47 cultivars were compared and classified based on fingerprints and chemical components obtained using HPLC-PDA-MS/MS combined with chemometric methods. Three pattern recognition methods, namely, hierarchical cluster analysis, principal component analysis, and partial least square-discriminant analysis, were used to establish classification models. Results showed that the contents of 10 components from pomegranate peel were determined.
View Article and Find Full Text PDFBiomed Chromatogr
October 2025
Department of Rehabilitation, Nan'ao People's Hospital, Shenzhen, China.
Chrysotobibenzyl, a bioactive ingredient from Dendrobium chrysotoxum, exhibits potent anti-tumor activity. However, its metabolic profiles remain unelucidated. This study aimed to disclose the metabolic fates of chrysotobibenzyl using human liver fractions.
View Article and Find Full Text PDFChem Pharm Bull (Tokyo)
September 2025
National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki 210-9501, Japan.
The development of analytical techniques applicable to powdered pharmaceutical co-crystals, including those containing excipients, represents a comprehensive strategy for quality control in both drug development and regulatory settings. This study investigates the structural characterization of indomethacin-nicotinamide co-crystals using a combination of microcrystal electron diffraction (microED), solid-state NMR (SSNMR), Raman spectroscopy, and powder X-ray diffraction (PXRD). MicroED analysis revealed the crystal structure of the co-crystal, while SSNMR measurements provided insights into the molecular interactions within the structure.
View Article and Find Full Text PDFJ Adv Res
September 2025
State Key Laboratory for Quality and Safety of Agro-Products, Key Laboratory for Pesticide Residue Detection of Ministry of Agriculture and Rural Affairs, Institute of Agro-Product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China. Electronic address: tangtao@za
Introduction: Microencapsulated pyraclostrobin (PYR-CS) has gained widespread adoption in agriculture owing to its extended efficacy and reduced risks for non-target organisms. However, knowledge remains limited regarding its degradation in soil and effects on soil microorganisms.
Objectives: This study investigates the hypothesis that microencapsulation alters pyraclostrobin degradation and reshapes soil microbial communities compared with conventional formulations, including emulsifiable concentrate (PYR-EC) and technical material (PYR-TC).