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http://dx.doi.org/10.1111/jth.15869 | DOI Listing |
JACC Case Rep
September 2025
Department of Cardiovascular Disease, Wellstar Kennestone Regional Medical Center, Marietta, Georgia, USA.
Background: Paragangliomas are rare neuroendocrine tumors arising from chromaffin cells, often associated with excess catecholamine production. Cardiac paragangliomas are particularly uncommon, accounting for <1% of all cardiac tumors.
Case Summary: We report a case of a right ventricular mass that was initially misidentified as a pericardial cyst on imaging but was ultimately diagnosed as a benign paraganglioma deriving from hereditary paraganglioma and pheochromocytoma syndrome after further diagnostic evaluation and treatment.
PLoS Biol
September 2025
The HIT Center for Life Sciences, Harbin Institute of Technology, Harbin, China.
Neuropeptide SIFamide (SIFa) neurons in Drosophila melanogaster have been characterized by their exceptionally elaborate arborization patterns, which extend from the brain into the ventral nerve cord (VNC). SIFa neurons are equipped to receive signals that integrate both internal physiological cues and external environmental stimuli. These signals enable the neurons to regulate energy balance, sleep patterns, metabolic status, and circadian timing.
View Article and Find Full Text PDFJ Med Cases
August 2025
Department of Cardiology, McLaren Health Care/Michigan State University, Flint, MI, USA.
Catecholamine-induced cardiomyopathy secondary to paraganglioma is a rare and potentially reversible condition. However, the course of recovery post-resection remains variable and may be delayed despite biochemical cure. We present the case of a 47-year-old male with biopsy-confirmed extra-adrenal paraganglioma who developed acute decompensated heart failure due to catecholamine-induced cardiomyopathy (left ventricular ejection fraction (LVEF) 30-35%) and multiorgan dysfunction.
View Article and Find Full Text PDFJ Med Cases
August 2025
Department of Urology, Hospital Universitario General de Villalba, Collado Villalba, Madrid, Spain.
Bladder paraganglioma accounts for < 0.05% of all bladder tumors, and very few cases have been reported to date. Because clinical and radiological findings are often nonspecific, many lesions are misdiagnosed until surgery, exposing patients to preventable perioperative catecholamine crises.
View Article and Find Full Text PDFAnal Chim Acta
October 2025
State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, PR China. Electronic address:
Mimicking the structure of natural laccase, we designed and synthesized a Cu-clusterzyme with Cu atom as the catalytic center, histidine and cysteine as the recognition unit and auxiliary fluorescence unit, respectively (denoted as Cys-His-CuNCs). Cys-His-CuNCs integrate the dual properties of laccase-like catalysis and fluorescence-sensing, and can simultaneously catalyze and detect the neurotransmitter epinephrine (EP). Cys-His-CuNCs exhibit a 44-fold higher catalytic activity than laccase.
View Article and Find Full Text PDF