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Objectives: Although personality characteristics of patients with SLE affect their disease activity and damage, it is unclear whether those of attending physicians affect the outcomes of patients with SLE. Grit is a personality trait for achieving long-term goals that may influence the decision-making for continuing treatment plans for patients. We aimed to evaluate the relationship between the grit of attending physicians and achievement of treatment goals in patients with SLE.
Methods: This cross-sectional study was conducted at five referral hospitals. The main exposure was 'consistency of interest' and 'perseverance of effort' of the attending physicians, measured by the Short Grit Scale. The primary outcome was achievement of a lupus low disease activity state (LLDAS). The association between physicians' grit score and LLDAS was analysed by generalized estimating equation (GEE) logistic regression with cluster robust variance estimation, with adjustment for confounders.
Results: The median (interquartile range) total, consistency and perseverance scores of 37 physicians were 3.1 (2.9-3.6), 3.3 (2.8-3.8) and 3.3 (3.0-3.5), respectively. Among the 386 patients, 154 (40%) had achieved LLDAS. Low consistency score (≤2.75) in physicians was related to LLDAS achievement independently using GEE logistic regression. The score of the question 'I often set a goal but later choose to pursue a different one' was significantly higher in patients achieving LLDAS.
Conclusions: Difficulty of attending physicians to change treatment goals might be related to lower LLDAS achievement in patients with SLE.
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http://dx.doi.org/10.1093/rheumatology/keac612 | DOI Listing |
Diabetes Ther
September 2025
Department of Diabetes and Endocrinology, Guy's and St Thomas' NHS Trust, London, UK.
Introduction: This post hoc analysis of an A Toujeo Observational Study (ATOS) aims to evaluate the real-world effectiveness and safety of insulin glargine 300 U/ml (Gla-300) in high-risk subgroups of insulin-naïve people with type 2 diabetes (PwT2D) from multiple geographical regions (Asia, the Middle East, North Africa, Latin America, and Eastern Europe).
Methods: In these post hoc analyses of ATOS, a real-world, 12-month, prospective study included 4422 insulin-naïve adults (age ≥ 18 years) with type 2 diabetes (T2D) uncontrolled (HbA > 7% and ≤ 11%) on one or more oral antidiabetic drugs (OADs) who initiated Gla-300 treatment as per routine practice. Primary and secondary endpoints were studied according to renal impairment (RI) status (without or with) and age group (≥ 70 years).
J Pain Res
August 2025
Department of Surgery, Pain Medicine Service, Charlie Norwood Veterans Administration Medical Center, Augusta, GA, USA.
Objective: Magnetic Peripheral Nerve Stimulation (mPNS) is an emerging neuromodulation therapy for chronic pain. We aimed to assess the safety and efficacy of mPNS in combination with CMM in patients with post-traumatic or post-surgical pain.
Materials And Methods: Safety and Efficacy of Axon Therapy (SEAT) was a prospective, randomized, multi-center study conducted across four clinical sites in the United States with 1 year follow-up.
Adv Med Educ Pract
September 2025
Department of Family and Community Medicine, College of Medicine, Taibah University, Madinah, Saudi Arabia.
Background: Artificial Intelligence (AI) is increasingly relevant tool to medical education and healthcare. Understanding the readiness of future physicians for AI integration is essential for developing effective curricula and fostering responsible use of this technology.
Methods: This cross-sectional study was conducted among 189 medical students at Taibah University using a validated, self-administered online questionnaire.
J Minim Invasive Gynecol
September 2025
Division of Minimally Invasive Gynecological Surgery, Department of Obstetrics and Gynecology, UConn Health - University of Connecticut, 263 Farmington Ave, Farmington CT 06030.
Study Objective: To assess the impact of surgeon gender on the timing of surgical intervention for ovarian torsion.
Design: This is a multi-center retrospective study of patients 18-50 years old, diagnosed with ovarian torsion between January 2012 and July 2023, and who underwent surgical management.
Setting: Multi-center, retrospective observational study.
Appl Clin Inform
August 2025
Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
Clinical decision support (CDS) tools in electronic health records (EHRs) often face low uptake due to limited usability, workflow integration, and other implementation issues. We recently designed and implemented the STRATIFY-CDS tool, which calculates a validated risk-prediction model and recommends disposition for emergency department (ED) patients with acute heart failure. Despite applying human-centered design and implementation science strategies, initial utilization in the first 3 months of the STRATIFY-CDS tool was just 3%.
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