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http://dx.doi.org/10.3389/fchem.2022.1042056 | DOI Listing |
Chem Res Toxicol
September 2025
Department of Chemistry, University of California Riverside, Riverside, California 92521-0403, United States.
NAR Cancer
September 2025
Department of Molecular Biology, Umeå University, 901 87 Umeå, Sweden.
Epitranscriptomic modifications regulate gene expression and have been implicated in cancer, including breast cancer. Using the SCAN-B cohort, we analyzed 49 messenger RNA modification regulators (mRMPs) across breast cancer subtypes. In the basal subtype, we found significant overexpression of mA readers (IGF2BP1-3), mC regulators (NSUN5, ALYREF, YBX1, YBX2), pseudouridine [PUS1, MARS (or MetRS), RPUSD2], and RNA editing enzymes [APOBEC3A (A3A), A3G, ADAR1], all linked to poor survival.
View Article and Find Full Text PDFFront Immunol
August 2025
Children's Hospital of Fudan University, National Children's Medical Center, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai, Chin
Front Cell Dev Biol
August 2025
Laboratory of Rheumatology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Introduction: Nephropathic cystinosis is a rare genetic disorder characterized by cystine accumulation in lysosomes that causes early renal dysfunction and progressive chronic kidney disease. Although several metabolic pathways, including oxidative stress and inflammation, have been implicated in the progression of renal parenchyma damage, the precise mechanisms driving its progression are not fully understood. Recent studies suggest that epigenetic modifications, particularly DNA methylation (DNAm), play a critical role in the development of chronic kidney disease.
View Article and Find Full Text PDFBiomacromolecules
September 2025
Department of Fibre and Polymer Technology, KTH Royal Institute of Technology, Teknikringen 58, Stockholm 10044, Sweden.
Lignin, traditionally considered a low-value byproduct of the pulp and paper industry, has gained significant attention in recent years as a sustainable precursor for the development of functional materials. This paradigm shift is driven by recent studies exploring the structure-property-performance relationships of lignin-based functional materials, which have provided valuable insights for selective chemical functionalization or pretreatment of lignin. Furthermore, the use of complementary analytical techniques has helped to shed light into lignin's complex and heterogeneous structure, opening new avenues for chemical modification.
View Article and Find Full Text PDF