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The search for dynamically screening the coupling between the scalar field and matter in high-density environment is achievable with the symmetron model. The high-accuracy and short-range gravity experiment is proposed to test the symmetron model. In this Letter, the data of the HUST-2020 torsion pendulum experiment testing the inverse-square law at submillimeter range is analyzed to constrain the symmetron model. The results show that the HUST-2020 experiment is uniquely sensitive to probe the symmetron model with a mass scale of μ=7.2×10^{-3} eV, and the self-coupling parameter λ≲105 is excluded at mass scale M=0.3 TeV. Especially, at the dark energy scale μ=2.4×10^{-3} eV, the constraint at M=1.3 TeV is improved by about 10 times the previous constraints on the torsion pendulum experiment.
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http://dx.doi.org/10.1103/PhysRevLett.129.141101 | DOI Listing |
Schizophr Res
September 2025
Queensland University of Technology (QUT), School of Psychology and Counselling, Brisbane, Australia; Queensland University of Technology (QUT), Centre for Inclusive Education (C4IE), Brisbane, Australia; King's College London, Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiat
Distinct patterns in the premorbid development of verbal and performance intelligence might differentiate the propensity for later illness among individuals putatively at risk for schizophrenia. This study applied linear mixed-effects models to four verbal and performance intelligence assessments gathered from a community sample of youth (n = 114) over ages 9-20 years, comparing developmental trajectories for at-risk youth with a triad of well-replicated antecedents of schizophrenia (ASz) and at-risk youth with a family history of schizophrenia (FHx), each relative to low-risk, typically developing peers (TD). Supplementary analyses explored heterogeneity among ASz youth according to persistence of symptoms, and FHx youth according to familial loading and presence of antecedents.
View Article and Find Full Text PDFSoc Psychiatry Psychiatr Epidemiol
April 2025
Department of Clinical Neuroscience, Division of Insurance Medicine, Karolinska Institutet, Stockholm, Sweden.
Background: It is not known if there are differences in antipsychotic initiation between migrants and native-born individuals diagnosed with non-affective psychotic disorder. This study aimed to determine (1) potential differences in initiation rate and type of first antipsychotic medication between refugees, non-refugee migrants, second-generation migrants, and Swedish-born young adults with incident non-affective psychosis and (2) which sociodemographic and clinical factors are associated with initiation.
Methods: This register-based cohort included 12,960 adults aged 18-35 years, residing in Sweden during 2007-2018, with an incident diagnosis of a non-affective psychotic disorder in inpatient or specialised outpatient care.
BMJ Ment Health
March 2025
Division of Insurance Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
Background: Psychotic disorders are known to exhibit heterogeneity with regards to illness course and prognosis, yet few studies have examined long-term healthcare use.
Objective: To determine the prevalence and predictors of healthcare use for psychiatric disorders at 9 years after the first episode of psychosis (FEP).
Methods: National registers were used to identify all Swedish residents aged 18-35 years with FEP between 2006 and 2013.
Psychoneuroendocrinology
March 2025
King's College London, Institute of Psychiatry, Psychology & Neuroscience, Department of Psychosis Studies, London, UK; National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, London, UK;
Background: Studies of salivary cortisol levels in psychosis have yielded inconsistent findings, which may be attributable to heterogeneity in cortisol measurement, illness stage, and approaches to dealing with sampling factors and potential confounders. To address these issues, we performed an individual participant data (IPD) meta-analysis comparing individuals at different stages of psychosis to controls using five different salivary cortisol measures and explored potential effect modifiers.
Methods: Salivary cortisol data from five London-based cohorts were used to derive the cortisol awakening response, total daytime cortisol output, basal cortisol, and diurnal slope measures (wake-to-evening and peak-to-evening).