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Article Abstract
Background: This study aims to find a correlation between spp. oral colonisation prior to radiotherapy (RT) and (i) the development of severe oral mucositis (OM) (grade 3/4) and (ii) early development of severe OM (EOM).
Methods: The protocol was registered on ClinicalTrials.gov (ID: NCT04009161) and approved by the ethical committee of the 'Fondazione Policlinico Universitario Gemelli IRCCS' (22858/18). An oral swab was obtained before RT to assess the presence of spp. Severe OM occurring before a dose of 40 Gy was defined as EOM.
Results: No patient developed G4 OM, and only 36/152 patients (23.7%) developed G3 OM. Tumour site and lymphocytopenia were risk factors for severe OM (OR for tumour site: 1.29, 95% CI: 1-1.67, = 0.05; OR for lymphocytopenia: 8.2, 95% CI: 1.2-55.8, = 0.03). We found a correlation between spp. and EOM (OR: 5.13; 95% CI: 1.23-21.4 = 0.04). Patients with oral colonisation of spp. developed severe OM at a mean dose of 38.3 Gy (range: 28-58; SD: 7.6), while negative patients did so at a mean dose of 45.6 Gy (range: 30-66; SD: 11.1).
Conclusions: spp. in the oral cavity appears to be a predictive factor of EOM.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9564084 | PMC |
| http://dx.doi.org/10.3390/cancers14194746 | DOI Listing |
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