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Probiotics are known as the live microorganisms which upon adequate administration elicit a health beneficial response inside the host by decreasing the luminal pH, eliminating the pathogenic bacteria in the gut as well as producing short chain fatty acids (SCFA). With advancements in research; probiotics have been explored as potential ingredients in foods. However, their use and applications in food industry have been limited due to restrictions of maintaining the viability of probiotic cells and targeting the successful delivery to gut. Encapsulation techniques have significant influence on increasing the viability rates of probiotic cells with the successful delivery of cells to the target site. Moreover, encapsulating techniques also prevent the live cells from harsh physiological conditions of gut. This review discusses several encapsulating techniques as well as materials derived from natural sources and nutraceutical compounds. In addition to this, this paper also comprehensively discusses the factors affecting the probiotics viability and evaluation of successful release and survival of probiotics under simulated gastric, intestinal conditions as well as bile, acid tolerant conditions. Lastly applications and challenges of using encapsulated bacteria in food industry for the development of novel functional foods have also been discussed in detail too. Future studies must include investigating the use of encapsulated bacterial formulations in models for effective health beneficial properties as well as exploring the mechanisms behind the successful release of these formulations in gut, hence helping us to understand the encapsulation of probiotic cells in a meticulous manner.
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http://dx.doi.org/10.3389/fnut.2022.971784 | DOI Listing |
J Therm Biol
September 2025
Department of Animal and Diary Sciences, University of Wisconsin, Madison, USA.
Owing to the anti-inflammatory and anti-oxidant benefits of Saccharomyces cerevisiae (SC), 20 mature male albino rats, assigned into four groups (A-D; n = 5), were used to investigate its ameliorative effects on heat stress-induced testicular and humoral alterations. Group A rats were neither treated with SC nor exposed to heat [-SC, -HS]. Group B rats were treated with 7 mg/kg of SC, but were not exposed to heat [+SC, -HS].
View Article and Find Full Text PDFFront Immunol
September 2025
Department of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha, Qatar.
Cancer is a multifaceted disease driven by a complex interplay of genetic predisposition, environmental factors and lifestyle habits. With the accelerating pace of cancer research, the gut microbiome has emerged as a critical modulator of human health and immunity. Disruption in the gut microbial populations and diversity, known as dysbiosis, has been linked with the development of chronic inflammation, oncogenesis, angiogenesis and metastasis.
View Article and Find Full Text PDFVet World
July 2025
Akkhraratchakumari Veterinary College, Walailak University, Nakhon Si Thammarat, 80160, Thailand.
Background And Aim: Probiotic viability remains a critical challenge during gastrointestinal (GI) transit, storage, and feed processing. Conventional encapsulation materials often fail under acidic and thermal stress. This study aimed to develop and characterize a novel, eco-friendly microencapsulation system using (FP) seed extract as a natural encapsulating matrix for (LP) WU2502, enhancing its functional resilience and storage stability.
View Article and Find Full Text PDFEur J Pharm Biopharm
September 2025
Technische Universität Braunschweig, Institute for Particle Technology, Volkmaroder Straße 5, 38104 Braunschweig, Germany; Technische Universität Braunschweig, Center of Pharmaceutical Engineering, Franz-Liszt-Straße 35A, 38106 Braunschweig, Germany.
In order to be able to administer efficient probiotic formulations, it is necessary to process the respective microorganisms gently into suitable dosage forms such as tablets maintaining their viability. In previous studies, the process chain consisting of fluidized bed granulation for life-sustaining drying of Saccharomyces cerevisiae as well as subsequent processing into tablets was investigated. Granules based on dicalcium phosphate (DCP), lactose (LAC) and microcrystalline cellulose (MCC) as carrier materials were produced and tableted, and physical-mechanical as well as microbiological tablet properties were evaluated.
View Article and Find Full Text PDFJ Pharmacol Exp Ther
July 2025
Department of Pharmacy Practice, Parul Institute of Pharmacy & Research, Parul University, Limda, Waghodia, Vadodara, Gujarat, India. Electronic address:
Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by widespread inflammation and immune system dysregulation. Recent research suggests that the gut microbiota may play a role in the development of SLE by modulating immune system responses, affecting cytokine production, and altering the activity of T and B cells lymphocytes. As a result, there is a growing interest in microbiota-targeted therapies, including probiotics, dietary changes, and fecal microbiota transplantation.
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