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Article Abstract
Unlabelled: The objective of this study is to assess the effect of neonatal procedures on glucose variability in very preterm infants. Preterm infants (≤ 32 weeks gestation and/or birthweight ≤ 1500 g) were started on continuous glucose monitoring (CGM) on day 2 of birth and monitored for 5 days. Minimally invasive (heel stick, venipunctures) and non-invasive (nappy change, parental presence) procedures were recorded. CGM data were analyzed 30 min before and after each procedure. The primary outcome was the coefficient of glucose variation (CV = SD/mean) before and after the procedure; SD and median glucose were also evaluated. We analyzed 496 procedures in 22 neonates (GA 30.5 weeks [29-31]; birthweight 1300 g [950-1476]). Median glucose did not change before and after each procedure, while CV and SD increased after heel prick (p = 0.017 and 0.030), venipuncture (p = 0.010 and 0.030), and nappy change (p < 0.001 and < 0.001), in the absence of a difference during parental presence.
Conclusions: Non-invasive and minimally invasive procedures increase glucose variability in the absence of changes of mean glucose.
What Is Known: • Minimally invasive procedures - including nappy change - may increase neonatal stress in preterm infants.
What Is New: • Continuous glucose monitoring provides a quantitative measure of neonatal stress during neonatal care procedures demonstrating an increase of glucose variability.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829573 | PMC |
| http://dx.doi.org/10.1007/s00431-022-04641-2 | DOI Listing |
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