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Background: Type two autoimmune pancreatitis is a rare and difficult to diagnose, steroid responsive non-IgG4 inflammatory pancreatopathy that can be associated with inflammatory bowel disease.
Case Summary: This case series describes three cases with varied clinical presentations and re-presentations of autoimmune pancreatitis, and all associated with an aggressive course of ulcerative colitis. The pancreatopathy was independent of bowel disease activity and developed in one case following colectomy.
Conclusion: Clinician awareness about this condition is important to allow early diagnosis, treatment and avoid unnecessary pancreatic surgery.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9453340 | PMC |
http://dx.doi.org/10.12998/wjcc.v10.i24.8788 | DOI Listing |
Clin Exp Immunol
September 2025
Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan.
Introduction: Conventional dendritic cells (cDCs) in the gut express the vitamin A (VA)-converting enzyme retinal dehydrogenase 2 (RALDH2) and produce significant amounts of retinoic acid (RA). RA derived from gut cDCs contributes to the generation of tolerogenic responses by promoting Treg differentiation while inhibiting Th1 and Th17 cell differentiation. In this study, we investigated whether similar RA-mediated immunoregulatory mechanisms operate in the pancreas using an experimental autoimmune pancreatitis (AIP) model.
View Article and Find Full Text PDFHemodial Int
September 2025
Department of Nephrology, Qingdao Central Hospital, University of Health and Rehabilitation Sciences, Qingdao, China.
Double-filtration plasmapheresis is an advanced extracorporeal blood purification technique that selectively removes pathogenic macromolecules based on molecular weight. Unlike conventional plasma exchange, double-filtration plasmapheresis uses a two-step filtration process to retain beneficial plasma components such as albumin, while eliminating harmful substances, thereby reducing the need for exogenous plasma replacement. Over the last few decades, double-filtration plasmapheresis has gained prominence in the management of refractory autoimmune, neurological, metabolic, and renal diseases.
View Article and Find Full Text PDFTher Adv Chronic Dis
September 2025
Department of Gastroenterology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Background: Type 1 autoimmune pancreatitis (AIP) is more prevalent among males, a significant proportion of whom are known to smoke and consume alcohol, both of which can cause damage to the pancreas. AIP is associated with the new-onset impaired glucose metabolism (NO-IGM). However, it remains unclear whether smoking and alcohol consumption exacerbate this risk.
View Article and Find Full Text PDFInt J Cancer
September 2025
Tampere Center for Child, Adolescent, Maternal Health Research and Tays Cancer Center, Tampere University and Tampere University Hospital, Tampere, Finland.
Etiology of childhood acute leukemia is largely unknown, though environmental factors and infection-related immune responses may contribute. Type 1 diabetes mellitus (T1DM), an autoimmune disease also with onset primarily in childhood, shares risk factors with leukemia, including childhood infection patterns. Epidemiological evidence suggests a link between T1DM and leukemia, but the extent of this association remains unclear.
View Article and Find Full Text PDFClin J Gastroenterol
September 2025
Department of Internal Medicine, Tsuyama Chuo Hospital, Tsuyama, Japan.
We report a case of obstructive jaundice due to recurrent distal biliary stricture during 3 years of treatment for immunoglobulin G4 (IgG4)-related sclerosing cholangitis (IgG4-SC) associated with autoimmune pancreatitis. Although a relapse of IgG4-SC was initially suspected, imaging findings, laboratory tests, and histopathological examinations led to the diagnosis of metachronous cholangiocarcinoma. The patient underwent pancreaticoduodenectomy, and no cancer recurrence was noted 6 months postoperatively.
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