Automated analysis of three-dimensional CBCT images taken in natural head position that combines facial profile processing and multiple deep-learning models.

Background And Objectives: Analyzing three-dimensional cone beam computed tomography (CBCT) images has become an indispensable procedure for diagnosis and treatment planning of orthodontic patients. Artificial intelligence, especially deep-learning techniques for analyzing image data, shows great potential for medical and dental image analysis and diagnosis. To explore the feasibility of automating measurement of 13 geometric parameters from three-dimensional cone beam computed tomography images taken in natural head position (NHP), this study proposed a smart system that combined a facial profile analysis algorithm with deep-learning models.

Materials And Methods: Using multiple views extracted from the cone beam computed tomography data of 170 cases as a dataset, our proposed method automatically calculated 13 dental parameters by partitioning, detecting regions of interest, and extracting the facial profile. Subsequently, Mask-RCNN, a trained decentralized convolutional neural network was applied to detect 23 landmarks. All the techniques were integrated into a software application with a graphical user interface designed for user convenience. To demonstrate the system's ability to replace human experts, 30 CBCT data were selected for validation. Two orthodontists and one advanced general dentist located required landmarks by using a commercial dental program. The differences between manual and developed methods were calculated and reported as the errors.

Results: The intraclass correlation coefficients (ICCs) and 95% confidence interval (95% CI) for intra-observer reliability were 0.98 (0.97-0.99) for observer 1; 0.95 (0.93-0.97) for observer 2; 0.98 (0.97-0.99) for observer 3 after measuring 13 parameters two times at two weeks interval. The combined ICC for intra-observer reliability was 0.97. The ICCs and 95% CI for inter-observer reliability were 0.94 (0.91-0.97). The mean absolute value of deviation was around 1 mm for the length parameters, and smaller than 2° for angle parameters. Furthermore, ANOVA test demonstrated the consistency between the measurements of the proposed method and those of human experts statistically (F=2.68, ɑ=0.05).

Conclusions: The proposed system demonstrated the high consistency with the manual measurements of human experts and its applicability. This method aimed to help human experts save time and efforts for analyzing three-dimensional CBCT images of orthodontic patients.