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Objective: To evaluate the influence of transfer quality and demographics on fear of falling (FOF) among full-time wheelchair users.
Design: Secondary data analysis.
Setting: University research laboratory and community, United States.
Participants: Ninety-six individuals (N=96) living with multiple sclerosis or spinal cord injury who use a manual or power scooter full time with median age of 54.00 years (interquartile range, 29.00 years), and median duration of health condition of 19.50 years (interquartile range, 23.00 years) were included. Fifty-two participants (54%) were manual wheelchair users.
Interventions: Not applicable.
Main Outcome Measures: Demographics information included age, sex, duration of health condition, height, weight, body mass index, and wheelchair type. To assess transfer quality, the Transfer Assessment Instrument versions 3.0 and 4.0 were used. The Spinal Cord Injury Falls Concern Scale was used to quantify FOF. Stepwise linear regression analysis was conducted to examine factors influencing FOF.
Results: Participant's age, sex, duration of health condition, wheelchair type, and transfer quality were associated with FOF. The regression analysis indicated transfer quality (β=-0.25, P<.01) and wheelchair type (manual wheelchair, β=- 0.32, P<.01) were significant predictors of FOF, R=20% (F=11.19; P<.01).
Conclusions: Compared with manual wheelchair users, power wheelchair/scooter users with poor transfer quality reported higher levels of FOF. Clinicians and researchers working with wheelchair users should emphasize quality of transfers and consider the type of wheelchair while developing interventions to reduce FOF in this population. Further longitudinal prospective studies on modifiable factors associated with FOF among full-time wheelchair users are warranted.
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http://dx.doi.org/10.1016/j.apmr.2022.09.002 | DOI Listing |
J Appl Clin Med Phys
September 2025
Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia, USA.
Purpose: Real‑time magnetic resonance-guided radiation therapy (MRgRT) integrates MRI with a linear accelerator (Linac) for gating and adaptive radiotherapy, which requires robust image‑quality assurance over a large field of view (FOV). Specialized phantoms capable of accommodating this extensive FOV are therefore essential. This study compares the performance of four commercial MRI phantoms on a 0.
View Article and Find Full Text PDFHosp Pediatr
September 2025
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Background: Direct admission can help reduce emergency department crowding, improve patient satisfaction, and decrease costs, yet there is opportunity to improve standardized processes to do so safely and efficiently. We designed and implemented a new process for urgent direct admission (UDA) at our children's hospital with the SMART (specific, measurable, achievable, relevant, time-bound) aim to increase the number of UDAs between transfer to an intensive care unit (ICU) within 12 hours from direct admission by 50% in 12 months.
Methods: We compared unanticipated ICU transfers within 12 hours of admission (outcome) before and after implementing a standardized UDA process.
Eur J Pharm Biopharm
September 2025
Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China. Electronic address:
Prodrugs with enzymatic activation requirements, such as the weakly basic biopharmaceutical classification system (BCS) class IV compound abiraterone acetate (ABA), face considerable bioequivalence (BE) risks owing to their pH-dependent solubility, food effects, and variable intestinal hydrolysis. This study established clinically relevant dissolution specifications for ABA using biorelevant dissolution and physiologically based biopharmaceutics modelling (PBBM). Two dissolution methods, two-stage (gastrointestinal transfer simulation) and single-phase (biorelevant media), were evaluated under fasted and fed conditions.
View Article and Find Full Text PDFJ Environ Manage
September 2025
State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, 100012, China.
Dissolved oxygen (DO) is a key water quality indicator reflecting river health. Modeling and understanding the spatiotemporal dynamics of DO and its influencing factors are crucial for effective river management. Machine learning (ML) models have gained popularity in water quality prediction; however, their accuracy strongly depends on the predictor variables.
View Article and Find Full Text PDFJ Agric Food Chem
September 2025
Department of Biotechnology, Graduate School of Engineering, The University of Osaka, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
During brewing processes, proteins such as lipid transfer protein 1 (LTP1) are exposed to high temperatures, which later affects the beer foam properties. To develop high-quality beer, it is therefore essential to understand the protein chemical modifications and structural alternations induced by the high temperatures and their impact on beer foam. This study characterizes heat-induced chemical modifications and changes in the molecular size distribution and structure of LTP1 and its lipid-bound isoform, LTP1b, using size-exclusion chromatography and reverse-phase chromatography/mass spectrometry.
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