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Objectives: The primary objective of this study was to measure the risk of return Emergency Department (ED) visits in patients presenting to the ED with a diagnosis of substance-induced psychosis. Secondary objectives included: (1) describing the characteristics of patients returning within 30 days to the ED with substance-induced psychosis, and (2) identifying risk factors associated with such ED return.
Methods: At two urban sites from January 1, 2018 to December 31, 2019, we included consecutive patients presenting to the ED with substance-induced psychosis defined by their ED discharge diagnosis of psychosis and clinical evidence of substance use. We described ED resources utilized by this patient population including ED time and disposition then subsequently described return visits within 30 days and characteristics among those patients who returned.
Results: We identified 611 unique patients presenting with substance-induced psychosis, with 813 total ED visits. The median age was 35 years (IQR 28-45), 71.4% (n = 436) were male, and 44.8% (n = 274) were homeless. The median ED length of stay was 619 min (IQR 313-898), and 48.4% (n = 296) were admitted to hospital. Forty percent of patients (n = 237) returned to the ED within 30 days of the index substance-induced psychosis visit, 116 (18.9%) returning more than once. Of these return visits, 74 (31.2%) were for recurrent substance-induced psychosis. Younger age, female gender, no opioid use, and no prior history of bipolar disorder were identified as common characteristics among those returning to the ED with substance-induced psychosis.
Conclusions: In ED patients with substance-induced psychosis, nearly half of all patients were admitted to hospital, 40% had a 30 days return ED visit, and one-third of those were for substance-induced psychosis. We identified clinically relevant factors common to those returning with recurrent substance-induced psychosis.
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http://dx.doi.org/10.1007/s43678-022-00364-3 | DOI Listing |
J Clin Psychopharmacol
September 2025
LVR Institute for Research and Education, Department of Research.
Background: The objective of this study was to characterize real-world prescription patterns of antipsychotic drugs in patients with various psychiatric disorders with psychotic features.
Method: We analyzed the discharge prescription plans of 59,962 cases with the main diagnoses schizophrenia, schizoaffective disorder, acute transient psychotic disorder, delusional disorder, psychotic bipolar disorder, psychotic depression, organic delusional disorder or substance-induced psychosis. We analyzed the overall use, pharmacological subgroups, the use of long-acting injectable (LAI) formulations, and the frequency of prescription of the singular antipsychotic drugs.
Schizophr Res Cogn
December 2025
Department of Psychiatry, Medical University and University Hospital Pleven, 113 Storgozia district, 5800 Pleven, Bulgaria.
Background And Hypothesis: psychotic disorders induced by substances like marijuana, amphetamines and methamphetamines (SIPDs) are a growing mental health problem, yet the question do they represent a separate psychotic class independent from schizophrenia (SZ) still stands. Studies comparing clinical and cognitive performance of SIPD and SZ patients have produced inconsistent results.
Study Design: we performed a cross-sectional analysis of 62 subjects divided into two statistically matched groups ( = 31 each) with SZ and SIPD respectively.
J Clin Med
August 2025
UniCamillus, International Medical University in Rome, Via di Sant'Alessandro 8, 00131 Rome, Italy.
Substance-induced psychosis is a recognized clinical entity, commonly linked to cannabinoids, stimulants, hallucinogens, alcohol, and polysubstance use. These agents may provoke transient or persistent psychotic symptoms during intoxication or withdrawal. Opioids, however, constitute a noteworthy exception: psychosis is rarely observed during opioid intoxication, and emerging data suggest that opioid agonists might even exert antipsychotic-like effects.
View Article and Find Full Text PDFThe treatment of attention-deficit/hyperactivity disorder (ADHD) largely involves the pharmacological restoration of dopaminergic hypoactivity in the brain, specifically in the prefrontal cortex. A disruption in dopaminergic neurotransmission is also seen in schizophrenia and psychosis, where there is a hyperactivity of this neurotransmitter. In our case study, a man with ADHD developed psychosis during treatment with stimulants.
View Article and Find Full Text PDFSoc Psychiatry Psychiatr Epidemiol
July 2025
Psychiatry East Region Zealand, Smedegade 16, Roskilde, 4000, Denmark.
Purpose: Psychiatric disorder is a well-established risk factor for homelessness, and homelessness amplifies social, physical, and mental health risks. Yet, little is known about the extent and nature of diagnostic delays, including the duration of untreated psychosis (DUP), among homeless individuals with schizophrenia. This study aimed to address that gap by examining DUP, diagnostic delays, illness trajectories, psychopathology, and substance use in this population.
View Article and Find Full Text PDF