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During the last quarter of 2019, the beaches, mangroves, and estuaries of Northeast Brazil received an unprecedented volume of crude oil from the sea, which became the worst environmental disaster ever to reach the Brazilian coast. The oil, having reached the shores completely unnoticed, left both society and government agents completely clueless on (i) where the oil was coming from; (ii) how much oil was still in the ocean to reach the shorelines; and (iii) which beaches were going to be affected next! By exploring remote sensing data and ocean numerical modeling, along with oil dispersion chemistry on sea water, this study investigates the possible origin and path of the spill and whether it could have been detected from space. The oil dispersion modeling simulations performed for this investigation revealed a possible region and timing of the oil spill, also indicating the likelihood of it being advected toward the shoreline under the ocean surface.
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http://dx.doi.org/10.1590/0001-3765202220210391 | DOI Listing |
J Environ Manage
September 2025
Department of Sanitary and Environmental Engineering. Federal University of Santa Catarina, Santa Catarina, Brazil. Electronic address:
Controlling vehicular emissions is a critical priority, particularly in developing countries like Brazil, where the vehicular fleet has expanded significantly. Although Brazil's Program to Control Vehicular Emissions has reduced certain air pollutants by mandating technological advancements in new vehicles, it did not consider the substantial increase in vehicle numbers and density across the country. To date, no comprehensive national-scale evaluation has been conducted to assess the program's effectiveness in Brazil.
View Article and Find Full Text PDFEpidemiol Serv Saude
September 2025
Universidade Federal de Goiás, Instituto de Patologia Tropical e Saúde Pública, Departamento de Saúde Coletiva, Goiânia, GO, Brazil.
Objective: To investigate association between the sociodemographic profiles of individuals with oral cancer in Brazil and the time interval between diagnosis and initiation of treatment.
Methods: This was a cross-sectional study of reported oral cancer cases in Brazil from 2011 to 2020, using data from the Cancer Hospital Registry Information System of the Brazilian National Cancer Institute (Sis-RHC/INCA). Sociodemographic profiles were identified using two-step cluster analysis, and associations were estimated using multinomial logistic regression, with odds ratios (OR) and 95% confidence intervals (95%CI).
Acta Sci Neurol
April 2025
Division of Personalized Pain Therapy Research, Center for Advanced Spine Care of Southern Arizona, Tucson, AZ.,USA.
In spite of the ongoing exquisite work of a multitude of researchers worldwide including governmental institutions like the National Institute on Drug Abuse (NIDA) and the National Institute on Alcohol Abuse and Alcoholism (NIAAA), and for example in the United States the FDA Medication Assisted Therapy (MAT) embracing Opioid Replacement Therapy (ORT) in 2022, 111,000 people prematurely died from opioid induced overdose. It is estimated that if treatment stays as usual by 2025 the death rate will increase to 165,00.Therefore, we are encouraging the scientific and clinical community to at least consider our "out of the box" thinking whereby we are proposing a new paradigm shift involving the " dopaminergic homeostatic modeling approach and Genetic screening to early identify preaddiction.
View Article and Find Full Text PDFNaunyn Schmiedebergs Arch Pharmacol
September 2025
Department of Biophysics and Physiology - Federal University of Piauí, Teresina, Piaui, Brazil.
Sulcatone is a compound found in citrus fruits and citronella oil, and it exhibits biological effects on the cardiovascular system. This study aimed to investigate the pharmacokinetic and pharmacodynamic aspects of sulcatone through in silico analysis and to evaluate its vasorelaxant, antioxidant, and hemostatic effects in spontaneously hypertensive rats (SHR). To refine the investigation, in silico evaluation was performed using the ADMET-AI, SwissADME, Protox 3.
View Article and Find Full Text PDFActa Sci Neurol
April 2025
Department of Psychiatry, Texas Tech University Health Sciences, School of Medicine, Lubbock, TX., United States of America.
We examine the relationship between substance use disorder (SUD) and schizophrenia, emphasizing the role of dopaminergic neurotransmission and genetic predispositions within the context of Reward Deficiency Syndrome (RDS). Our hypothesis posits that a deficiency in gamma-type endorphins leads to persistent hyperdopaminergic activity, amplifying schizophrenia-related symptoms such as hallucinations. Thus, alcohol use may function as a physiological self-healing mechanism by increasing gamma-endorphin levels, thereby mitigating dopaminergic hyperactivity.
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