Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Since a stroke can impair bimanual activities, enhancing bimanual cooperation through motor skill learning may improve neurorehabilitation. Therefore, robotics and neuromodulation with transcranial direct current stimulation (tDCS) are promising approaches. To date, tDCS has failed to enhance bimanual motor control after stroke possibly because it was not integrating the hypothesis that the undamaged hemisphere becomes the major poststroke hub for bimanual control.
Objective: We tested the following hypotheses: (I) In patients with chronic hemiparetic stroke training on a robotic device, anodal tDCS applied over the primary motor cortex of the undamaged hemisphere enhances bimanual motor skill learning compared to sham tDCS. (II) The severity of impairment correlates with the effect of tDCS on bimanual motor skill learning. (III) Bimanual motor skill learning is less efficient in patients than in healthy individuals (HI).
Methods: A total of 17 patients with chronic hemiparetic stroke and 7 healthy individuals learned a complex bimanual cooperation skill on the REAplan neurorehabilitation robot. The bimanual speed/accuracy trade-off (biSAT), bimanual coordination (biCo), and bimanual force (biFOP) scores were computed for each performance. In patients, real/sham tDCS was applied in a crossover, randomized, double-blind approach.
Results: Compared to sham, real tDCS did not enhance bimanual motor skill learning, retention, or generalization in patients, and no correlation with impairment was noted. The healthy individuals performed better than patients on bimanual motor skill learning, but generalization was similar in both groups.
Conclusion: A short motor skill learning session with a robotic device resulted in the retention and generalization of a complex skill involving bimanual cooperation. The tDCS strategy that would best enhance bimanual motor skill learning after stroke remains unknown.
Clinical Trial Registration: https://clinicaltrials.gov/ct2/show/NCT02308852, identifier: NCT02308852.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433746 | PMC |
| http://dx.doi.org/10.3389/fneur.2022.882225 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Differences in Motor Competence Between Children and Adolescents With and Without ADHD: Findings from a Systematic Review and Meta-analysis.
J Autism Dev Disord
September 2025
Departamento de Didácticas Especiáis, Universidade de Vigo, 36310, Vigo, Spain.
Children and adolescents with Attention-Deficit/Hyperactivity Disorder (ADHD) are often reported to have motor skill deficits, though findings remain inconsistent across studies. To determine whether motor competence differs significantly between youth with ADHD and their typically developing (TD) peers through a systematic review and meta-analysis. Following PRISMA guidelines, four databases were searched up to May 2025.
View Article and Find Full Text PDFEmotion understanding in infants and young children: How input shapes emotional development.
Adv Child Dev Behav
September 2025
University of California, Davis, CA, USA.
Here, we will review the developmental literature on how infants and young children learn about emotions. We take a process-based perspective, highlighting how the protracted trajectory of emotional development unfolds concurrently with changes in children's cognitive abilities, and how variability based on context, culture, and experience shape this trajectory over time. We will also emphasize the role of input into this development, a factor that has often been ignored.
View Article and Find Full Text PDFFMR1 mutant marmosets show fragile X syndrome phenotypes.
Cell Rep
August 2025
Laboratory of Animal Resources, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. Electronic address:
Fragile X syndrome (FXS) is the foremost monogenic cause of autism spectrum disorder and intellectual disability, caused by FMR1 gene silencing. Here, we report that common marmosets carrying FMR1 mutation, a non-human primate model for FXS, share common features in behavioral and molecular phenotypes with patients with FXS. Founder mutants with markedly reduced fragile X messenger ribonucleoprotein expression display hyperactivity, spontaneous seizures, and transcriptome changes in synapse-related genes that overlap with those reported in patients with FXS.
View Article and Find Full Text PDFLiving with cough and secretion issues: the experiences of people with amyotrophic lateral sclerosis and their caregivers.
Disabil Rehabil
September 2025
Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK.
Purpose: To explore the experiences of people living with amyotrophic lateral sclerosis (ALS) and their caregivers managing cough and secretion problems.
Methods: A qualitative study was completed with 15 individuals participating in 10 interviews; 10 people living with ALS and five informal caregivers. Interview methods were adapted to ensure inclusivity of participants who had physical, respiratory and communication impairments.
Age- and gender-related normative values of the athletic skills track for 5- to 12-year-old spanish children.
J Sports Sci
September 2025
Faculty of Health, Nutrition & Sports, The Hague University of Applied Sciences, Den Haag, The Netherlands.
Although motor competence in children is considered an important component of an active lifestyle, there are not many product-oriented tools to assess it in primary school settings. Therefore, the aim of this cross-sectional study was to provide age- and gender-related normative values for the Athletic Skill Track (AST-1, AST-2 and AST-3) for Spanish children from 5 to 12 years old (M = 8.73 ± 2.
View Article and Find Full Text PDF