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Chronic exertional compartment syndrome (CECS) is a commonly missed diagnosis. It is caused by an increase in intramuscular pressure which subsequently impedes local tissue perfusion and function. It disproportionately occurs in young females; however, the diagnosis should not be excluded in other demographics. We present a case of CECS in an otherwise healthy 53-year-old male fire captain. He presented with pain upon exertion and neurological deficits in the anterior compartment of his bilateral legs that impacted his occupation and daily functioning. Following fasciotomy, the patient returned to work with complete resolution of pain and neurological deficits. This review seeks to describe the prevalence, etiology, diagnostic criteria, differential diagnosis, and management of CECS of the lower extremities, as described in the literature.
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http://dx.doi.org/10.7759/cureus.27321 | DOI Listing |
Cureus
August 2025
Allergy and Immunology, Wilford Hall Medical Center, San Antonio, USA.
We present two patients who presented with symptoms that overlap with asthma, but upon further diagnostic evaluation, were revealed to have underlying malignancy. These cases highlight the importance of objective evidence-based evaluation in unveiling diagnoses previously mislabeled as asthma. The first patient was a 51-year-old with one year of cough and waning albuterol responsiveness, with worsening orthopnea and exertional dyspnea.
View Article and Find Full Text PDFBackground: Individuals with chronic obstructive pulmonary disease (COPD) often lead sedentary lives, which is linked to negative health outcomes. Understanding the causes of this behaviour is essential for designing effective interventions. In the time following a hospital discharge, people with COPD may be especially sedentary and develop habits that contribute to this behaviour.
View Article and Find Full Text PDFNPJ Metab Health Dis
September 2025
Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY, USA.
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by unexplained fatigue, post-exertional malaise (PEM), and cognitive dysfunction. ME/CFS patients often report a prodrome consistent with infection. We present a multi-omics analysis based on plasma metabolomic and proteomic profiling, and immune responses to microbial stimulation, before and after exercise.
View Article and Find Full Text PDFMedicine (Baltimore)
August 2025
Department of Physical Education of Sports Teaching, Faculty of Sports Sciences, Atatürk University, Erzurum, Turkey.
Background: This quasi-experimental crossover study aimed to examine the acute effects of dry cupping therapy (DCT) and neuromuscular electrical stimulation (NMES) on fatigue and perceived exertion in anaerobic performance among physically active individuals.
Methods: Twelve male participants (mean age: 24.1 ± 2.
Physiol Rep
September 2025
Division of Pulmonary, Critical Care, Sleep, and Allergy Medicine, University of Arizona, Tucson, Arizona, USA.
Post-acute sequelae of SARS-CoV-2 (PASC or "long COVID") and chronic fatigue syndrome/myalgic encephalitis (CFS/ME) share symptoms such as exertional dyspnea. We used exercise oxygen pathway analysis, comprising six parameters of oxygen transport and utilization, to identify limiting mechanisms in both conditions. Invasive cardiopulmonary exercise testing was performed on 15 PASC patients, 11 CFS/ME patients, and 11 controls.
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