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http://dx.doi.org/10.1212/WNL.0000000000201131 | DOI Listing |
Open Res Eur
September 2025
Clinical trial unit, Armauer Hansen Research Institute, Addis Ababa, 1005, Ethiopia.
Background: According to the Council of International Organizations and Medical Sciences (CIOMS) 2016, post-trial access (PTA) refers to the ethical imperative that requires the sponsor, researchers, and relevant public health authority, "to make available as soon as possible any intervention or product developed, and knowledge generated, for the population or community in which the research is carried out." Law, policy, and practical guidance for PTA has so far been vague but has recently attracted and increased attention in the context of benefit sharing of scientific research results with low- and middle-income countries (LMICs).Although the number of clinical trials conducted in the Sub Saharan (SSA) countries has increased in the past two decades, plans and practices for PTA are underreported.
View Article and Find Full Text PDFArch Pharm (Weinheim)
September 2025
Department of Biology, Faculty of Arts and Sciences, Cukurova University, Adana, Turkey.
l-Ascorbic acid exhibits paradoxical behavior as both antioxidant and pro-oxidant in cancer treatment, with mechanisms and optimal dosing remaining unclear. This in vitro study investigated l-ascorbic acid's effects on healthy lymphocytes and HL-60 leukemia cells using concentrations of 0.5-2 mg/mL for 6 and 24 h.
View Article and Find Full Text PDFPalliat Support Care
September 2025
REHPA, The Danish Knowledge Centre for Rehabilitation and Palliative Care, Odense University Hospital, Nyborg, Denmark.
Objectives: This study aimed to investigate healthcare professionals' experiences with using the PRO Palliative Care questionnaire (PRO-Pall) to identify palliative care symptoms and problems in non-specialized palliative care settings among patients with heart, lung, and kidney disease, and cancer. The study also investigated the PRO-Pall's potential to ensure further initiatives and care.
Methods: A national, multicenter, observational study employing a mixed-methods approach.
BMC Nurs
September 2025
Nursing Administration, Faculty of Nursing, Mansoura University, Mansoura, Egypt.
Borderline Personal Disord Emot Dysregul
September 2025
German Center for Mental Health (DZPG), partner site Munich, Munich, Germany.
Background: Emotion dysregulation is a central feature in trauma-associated disorders such as posttraumatic stress disorder (PTSD) and borderline personality disorder (BPD). However, it remains unclear whether emotion dysregulation is a transdiagnostic phenomenon closely linked to childhood trauma, or if disorder-specific alterations in emotion processing exist. Following a multimethodological approach, we aimed to assess and compare the reactivity to and regulation of emotions between patients with BPD and PTSD, as well as healthy controls, and identify associations with childhood trauma.
View Article and Find Full Text PDF