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| http://dx.doi.org/10.1016/j.jns.2022.120379 | DOI Listing |
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Meningovascular and parenchymal neurosyphilis showing more extensive inflammatory lesions on F-THK5351 PET than MRI.
Rinsho Shinkeigaku
May 2025
Department of Neurology, Tokyo Metropolitan Institute for Geriatrics and Gerontology.
This manuscript complements the clinical course of the first case of neurosyphilis in our previous report (Kotani. et al. Clin Nuc Med 2024) which highlighted the utility of F-THK5351 positron emission tomography (PET), a marker of astrogliosis, to visualize neuroinflammation.
View Article and Find Full Text PDF18 F-THK5351 PET Is Superior to Conventional MRI in Identifying Inflammatory Lesions by Imaging Astrogliosis in 2 Cases of Neurosyphilis.
Clin Nucl Med
December 2024
From the Department of Neurology.
18 F-labeled THK5351 PET can visualize ongoing astrogliosis by estimating monoamine oxidase B levels and can be used as a neuroinflammation marker for identifying inflammatory lesions by imaging astrogliosis. Assessment of its performance is of interest, especially when compared with conventional MRI. Here, we present 2 cases of neurosyphilis, in which 18 F-THK5351 PET identified inflammatory lesions by imaging astrogliosis, whereas MRI had difficulty detecting the lesions.
View Article and Find Full Text PDFHeterogeneity of factors associated with cognitive decline and cortical atrophy in early- versus late-onset Alzheimer's disease.
Sci Rep
September 2024
Neuroscience Research Institute, Gachon University, Incheon, Republic of Korea.
The objectives of this study were to investigate the variable factors associated with cognitive function and cortical atrophy and estimated variable importance of those factors in affecting cognitive function and cortical atrophy in patients with EOAD and LOAD. Patients with EOAD (n = 40), LOAD (n = 34), and healthy volunteers with normal cognition were included (n = 65). All of them performed 3T MRI, [F]THK5351 PET (THK), [F]flutemetamol PET (FLUTE), and detailed neuropsychological tests.
View Article and Find Full Text PDFDiverging Relationships among Amyloid, Tau, and Brain Atrophy in Early-Onset and Late-Onset Alzheimer's Disease.
Yonsei Med J
August 2024
Neuroscience Research Institute, Gachon University, Incheon, Korea.
Purpose: Alzheimer's disease (AD) dementia may not be a single disease entity. Early-onset AD (EOAD) and late-onset AD (LOAD) have been united under the same eponym of AD until now, but disentangling the heterogeneity according to the age of sonset has been a major tenet in the field of AD research.
Materials And Methods: Ninety-nine patients with AD (EOAD, n=54; LOAD, n=45) and 66 cognitively normal controls completed both [F]THK5351 and [F]flutemetamol (FLUTE) positron emission tomography scans along with structural magnetic resonance imaging and detailed neuropsychological tests.
Clinical Application of 18 F-THK5351 PET to Image Ongoing Astrogliosis in MSA-P and MSA-C.
Clin Nucl Med
October 2024
From the Department of Neurology.
18 F-labeled THK5351 PET can visualize ongoing astrogliosis by estimating monoamine oxidase B levels and can be used as an adjunct for diagnosing neurodegenerative disorders. Little has been reported on multiple system atrophy (MSA) in the differential diagnosis of parkinsonian syndromes. Here, we present 18 F-THK5351 images in typical cases of MSA-P (parkinsonian type) and MSA-C (cerebellar type), showing intense 18 F-THK5351 uptake in the lateral-posterior part of the putamen (MSA-P) and in the pons and middle cerebellar peduncles (MSA-C).
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