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http://dx.doi.org/10.3324/haematol.2022.281431 | DOI Listing |
Osteoarthr Cartil Open
September 2025
Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Section for Rheumatology and Molecular Skeletal Biology, Lund, Sweden.
Objectives: 1. To validate catabolic meniscus explant models induced by cytokines: interleukin-6 + interleukin-6 receptor + tumor necrosis factor alpha (IL6/TNF) and oncostatin M + tumor necrosis factor alpha (OSM/TNF). 2.
View Article and Find Full Text PDFIndian J Endocrinol Metab
August 2025
Department of Endocrinology, Bharti Hospital, Karnal, Haryana, India.
Metabolomics is a type of laboratory science used to understand the cellular and metabolic defects in any disease process. It comprehensively identifies endogenous and exogenous low-molecular-weight (<1 kDa) molecules or metabolites in a high-throughput manner. Mass spectrometry-based methods are used for metabolomics which can be targeted and non-targeted.
View Article and Find Full Text PDFMicrobes Infect
September 2025
Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland; ESCMID study group on Molecular Diagnostics and Genomics. Electronic address:
Rapid advancements in artificial intelligence (AI) and machine learning (ML) offer significant potential to transform medical microbiology diagnostics, improving pathogen identification, antimicrobial susceptibility prediction and outbreak detection. To address these opportunities and challenges, the ESCMID workshop, "Artificial Intelligence and Machine Learning in Medical Microbiology Diagnostics", was held in Zurich, Switzerland, from June 2-5, 2025. The course featured expert lectures, practical sessions and panel discussions covering foundational ML concepts and deep learning architectures, data interoperability, quality control processes, model development and validation strategies.
View Article and Find Full Text PDFJ Biol Chem
September 2025
Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan. Electronic address:
Posttranslational modifications (PTMs) of proteins are efficient biological mechanisms for expanding the genetic code and for regulating cellular physiology. However, there have been no systematic approaches to profile all the PTMs critical for autoreactive neoantigen production or the etiology and pathology of autoimmune diseases. In the present study, to gain insight into protein PTMs associated with systemic lupus erythematosus (SLE), we applied a mass spectrometry-based method for the comprehensive analysis of modified amino acids ("adductome").
View Article and Find Full Text PDFMar Pollut Bull
September 2025
Department of Chemistry, Kyungpook National University, Daegu 41566, Republic of Korea; Mass Spectrometry Based Converging Research Institute, Daegu 41566, Republic of Korea. Electronic address:
Polyethylene terephthalate (PET) is one of the most widely used plastics, particularly in packaging and textiles. Although PET is widely used in consumer products, only 10-28 % is recycled. Most PET waste is not properly managed.
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