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Medical Artificial Intelligence: Opportunities and Challenges In Infectious Disease Management.

Curr Med Chem

August 2025

Department of Pharmaceutical Sciences, Shalom Institute of Health and Allied Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences, Allahabad, 211007, Uttar Pradesh, India.

Globally, millions of individuals suffer from infectious diseases, which are major public health concerns caused by bacteria, fungi, viruses, or parasites. These diseases can be transmitted directly or indirectly from person to person, potentially leading to a pandemic or epidemic. Several advancements have been made in molecular genetics for infectious disease management, which include pharmaceutical chemistry, medicine, and infection tracking; however, these advancements still lack control over human infections.

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Background: We sought to investigate the association between circulating inflammatory and cardiovascular proteomics biomarkers and cardiac autonomic nervous dysfunction-sensitive heart rate variability indices.

Methods: Using the population-based KORA (Cooperative Health Research in the Region of Augsburg) cohort, 233 proteomics biomarkers were quantified in baseline plasma samples of 1389 individuals using proximity extension assay technology. Five heart rate variability indices (Rényi entropy of the histogram with order [α] 4, total power of the density spectra, SD of word sequence, SD of the short-term normal-to-normal interval variability, compression entropy) were assessed at baseline in 982 individuals and in 407 individuals at baseline and at 14-year follow-up.

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In recent years the treatment for heart failure (HF) has become much more complex. This development has highlighted the importance of a multidisciplinary HF team to ensure the best possible individually adapted treatment decisions, taking the patient's personal wishes into account and to achieve optimal results. In Germany, specialized HF practices, clinics and tertiary bespoke HF unit centers were established to ensure qualified care for HF patients.

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Fabrication of water-stable and atomically dispersed ruthenium catalysts for sustainable borrowing hydrogenation (BH) reactions is a long-standing challenge. Herein, we developed an atomically dispersed Ru catalyst that has been successfully employed for BH reactions in aqueous micelles under mild conditions. The micellar cooperativity with the hydrophobic knitted aryl polymers (KAPs) led to the formation of microconfinements, which act as the confined space for catalysis in water.

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Research on the construction method and characterization of neutralizing mouse-canine chimeric antibody against canine distemper virus.

Virology

August 2025

National Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, 430070, China; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Pr

Canine distemper (CD) is an acute infectious disease that poses significant health risks to canines. Neutralizing monoclonal antibody (mAb) therapy has demonstrated substantial efficacy in prevent CDV infection. However, immune rejection reactions prevent the use of mouse-derived mAbs in the prophylactic protection of CD.

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