Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Because of the increased risk of acute renal failure (ARF), the use of cyclooxygenase (COX) inhibitors is not recommended in patients with decompensated hepatic cirrhosis. Metamizole is not a classic COX inhibitor, but there are insufficient data to support its safe use. In this study, we investigate the effect of metamizole on the risk of ARF in these patients.
Methods: Metamizole use, ARF incidence, and patient mortality were examined in a large, retrospective, exploratory cohort and validated with data from a prospective registry.
Results: 523 patients were evaluated in the exploratory cohort. Metamizole use at baseline was documented in 110 cases (21%) and was independently associated with the development of ARF, severe (grade 3) ARF, and lower survival without liver transplantation at follow-up on day 28 (HR: 2.2, p < 0.001; HR: 2.8, p < 0.001; and HR: 2.6, p < 0.001, respectively). Interestingly, the risk of ARF depended on the dose of metamizole administered (HR: 1.038, p < 0.001). Compared to patients who were treated with opioids, the rate of ARF was higher in the metamizole group (49% vs. 79%, p = 0.014). An increased risk of ARF with metamizole use was also demonstrated in the independent validation cohort (p < 0.001).
Conclusion: Metamizole therapy, especially at high doses, should only be used with a high level of caution in patients with decompensated cirrhosis.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830680 | PMC |
| http://dx.doi.org/10.3238/arztebl.m2022.0280 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Bovine-derived collagen matrix as an adjunct in stage 3 pressure injuries: a case series of lower extremity wounds.
J Wound Care
September 2025
MIMEDX Group, Inc., Marietta, GA, US.
Objective: Hard-to-heal (chronic) stage 3 pressure injuries (PIs) in medically complex patients are often refractory to standard treatments, and pose significant risks of infection, limb loss and diminished quality of life. Adjunctive use of advanced biologic materials, such as bovine-derived collagen matrices, may support more efficient wound resolution in these high-risk populations.
Method: In this retrospective case series, patients with hard-to-heal stage 3 PIs of the lower extremity were treated with a single application of a bovine-derived collagen matrix as part of a multidisciplinary wound care protocol.
The Impact of Acute Rheumatic Fever Diagnosis on Rheumatic Heart Disease Severity.
Glob Heart
September 2025
Menzies School of Health Research and Royal Darwin Hospital, Northern Territory, Australia.
Background: Acute rheumatic fever (ARF) is the precursor to rheumatic heart disease (RHD) following Group A Streptococcal infection. However, many diagnoses of RHD are made in the absence of ARF history. We compared RHD severity between those with and those without a documented history of ARF.
View Article and Find Full Text PDFPredictors of Intensive Care Unit Outcomes in Elderly Patients with Acute Respiratory Failure: A Retrospective Cohort Study.
J Clin Med
August 2025
Division of Intensive Care Medicine, Department of Internal Medicine, Gazi University School of Medicine, Ankara 06500, Turkey.
: Acute respiratory failure (ARF), a major cause of intensive care unit (ICU) admission in elderly patients, is strongly associated with adverse outcomes. Despite its clinical significance, data on prognostic factors in this patient group remain limited. This study aims to identify key prognostic factors in elderly ICU patients with ARF to guide clinical management.
View Article and Find Full Text PDFIntroduction: High-flow nasal oxygen therapy (HFNO) for acute respiratory failure (ARF) has been used in the intensive care units (ICU), but more recently also on respiratory wards (RW). Little data are available regarding in-hospital, short-term and long-term mortality in the latter setting.
Methods: We performed a retrospective analysis of patients ≥ 16 years old treated with HFNO on the RW between 01/2020 and 09/2022 with a follow-up until 09/2023.
Clinical Significance of Respiratory Torque Teno Virus in Immunocompromised Patients with Acute Respiratory Failure.
Clin Microbiol Infect
August 2025
Service de Virologie, Hôpital Saint-Louis, Assistance Publique des Hôpitaux de Paris, F-75010 Paris, France; Université Paris Cité, Inserm U976, Insight team, F-75010 Paris, France. Electronic address:
Objective: Among immunocompromised patients with acute respiratory failure, identification of those at higher risk for opportunistic infections is crucial to optimize management. The Torque teno virus (TTV) DNA burden in the blood has been identified as a surrogate marker of functional immunity in solid organ transplant recipients. This study investigates the clinical relevance of TTV DNA in nasopharyngeal swabs of immunocompromised patients with acute respiratory failure (ARF).
View Article and Find Full Text PDF