Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Systemic anaplastic lymphoma kinase-negative (ALK-) anaplastic large cell lymphoma (ALCL) comprises a genomically heterogeneous disease that is considered a distinct entity by the 2016 World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues. Other than lymph nodes, systemic ALK- ALCL may affect extranodal tissues, sites where the inflammatory background may be especially prominent. In this scenario, myxoid change is exceptional in systemic ALK- ALCL. We describe a rare case of systemic ALK- ALCL with distinctive myxoid changes, carrying specific chromosomal aberrations that affect the clinical outcome. Careful morphological, immunohistochemical, and molecular workup is mandatory because a myxoid background should not be a reason to ignore the possibility of a lymphoma. Finally, extensive correlation with staging and the detection of prognostic biomarkers such as DUSP22 and TP63 rearrangements are essential for the diagnosis and prediction of clinical outcome in ALK- ALCL.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00428-022-03386-5 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[Primary lymphomas in urinary bladder: a clinicopathological analysis of 23 cases].
Zhonghua Bing Li Xue Za Zhi
September 2025
Department of Pathology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
To investigate the clinicopathological features, diagnosis and differential diagnosis of primary bladder lymphoma. A retrospective study was conducted on 23 cases of primary bladder lymphoma diagnosed at Beijing Friendship Hospital of Capital Medical University between February 2010 and April 2024. The clinicopathological data were collected and analyzed, and literature was reviewed.
View Article and Find Full Text PDFAnaplastic lymphoma kinase-positive primary CNS anaplastic large cell lymphoma in a pediatric patient: illustrative case.
J Neurosurg Case Lessons
September 2025
Department of Neurosurgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Background: Anaplastic lymphoma kinase (ALK)-positive primary CNS anaplastic large cell lymphoma (ALCL) is an extremely rare pediatric malignancy. Its radiological appearance often mimics infectious or glial lesions, complicating diagnosis and delaying treatment.
Observations: The authors report the case of a 10-year-old immunocompetent female who presented with absence seizures and vomiting.
Correction: Case Report: CAR-T therapy for primary cerebellar ALK-negative anaplastic large cell lymphoma.
Front Immunol
August 2025
Department of Hematology, Clinical Medical College & Affiliated Hospital of Chengdu University, Chengdu University, Chengdu, China.
[This corrects the article DOI: 10.3389/fimmu.2025.
View Article and Find Full Text PDFPrimary Gingival Anaplastic Lymphoma Kinase (ALK)-Positive Anaplastic Large Cell Lymphoma in a Young Boy.
Cureus
August 2025
Department of Odontology, Oral Medicine and Oral Surgery, Bretonneau Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP) Université Paris Cité, Paris, FRA.
Anaplastic large cell lymphoma (ALCL) is a rare non-Hodgkin lymphoma derived from natural killer (NK) or T-cells. It mainly affects lymph nodes, and less frequently, extranodal sites such as the skin, bone, or oral cavity. Lack of awareness of these extranodal manifestations can lead to delayed diagnosis, sometimes with dramatic consequences.
View Article and Find Full Text PDFComparative DNA Methylation Profiling of Human and Murine ALK-Positive B-Cell Neoplasms.
Genes Chromosomes Cancer
July 2025
Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, Germany.
Structural genomic variants leading to anaplastic lymphoma kinase (ALK) gene fusions and aberrant expression of the ALK tyrosine kinase are the hallmark of subtypes of T- and B-lineage neoplasms, namely ALK-positive anaplastic large lymphoma (ALCL) and ALK-positive large B-cell lymphoma (LBCL). The latter is a rare aggressive lymphoma, which has been initially identified as a variant of diffuse LBCL (DLBCL) with plasmablastic features. Here, we performed comparative DNA methylation profiling of human and murine ALK-positive B-cell neoplasms.
View Article and Find Full Text PDF