Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Copeptin is the carboxyl-terminus of the arginine vasopressin (AVP) precursor peptide. The main physiological functions of AVP are fluid and osmotic balance, cardiovascular homeostasis, and regulation of endocrine stress response. Copeptin, which is released in an equimolar mode with AVP from the neurohypophysis, has emerged as a stable and simple-to-measure surrogate marker of AVP and has displayed enormous potential in clinical practice. Cardiovascular disease (CVD) is currently recognized as a primary threat to the health of the population worldwide, and thus, rapid and effective approaches to identify individuals that are at high risk of, or have already developed CVD are required. Copeptin is a diagnostic and prognostic biomarker in CVD, including the rapid rule-out of acute myocardial infarction (AMI), mortality prediction in heart failure (HF), and stroke. This review summarizes and discusses the value of copeptin in the diagnosis, discrimination, and prognosis of CVD (AMI, HF, and stroke), as well as the caveats and prospects for the application of this potential biomarker.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289206 | PMC |
| http://dx.doi.org/10.3389/fcvm.2022.901990 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Copeptin in the diagnosis and management of renal tubular disorders.
Pediatr Nephrol
September 2025
Pediatric Nephrology Department, Biobizkaia Health Research Institute, Cruces University Hospital, Barakaldo, Spain.
Copeptin, a stable glycopeptide derived from the precursor of arginine vasopressin (AVP), has emerged as a valuable surrogate biomarker for AVP due to its stability and ease of measurement. This narrative review explores the physiological role of copeptin, its utility as a diagnostic and prognostic biomarker in different kidney diseases, and its clinical relevance in renal tubular disorders. The clinical application of copeptin as a diagnostic biomarker is best established in the differential diagnosis of polyuria-polydipsia syndrome (PPS), distinguishing nephrogenic diabetes insipidus (NDI) from central diabetes insipidus (CDI) and primary polydipsia (PP).
View Article and Find Full Text PDFPlasma Arginine Vasopressin and Serum Copeptin Concentrations at Rest and After Osmotic- and Non-Osmotic-Based Stimulation Tests in Dogs.
J Vet Intern Med
September 2025
Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Background: Serum copeptin (sCoP) is used as a surrogate for plasma arginine vasopressin (pAVP) measurement in humans.
Objective: To measure pAVP and sCoP at rest and after osmotic- and non-osmotic stimulation testing in dogs.
Animals: Eight young castrated/spayed healthy research Beagles, eight young intact dogs, and eight old neutered healthy client-owned dogs.
Development and Application in Stroke of an Aldehyde nanoparticle-based Amplified Luminescent Proximity Homogeneous Assay for Rapid Quantitative Measurement of Serum Copeptin.
J Fluoresc
August 2025
Department of Neurology, Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, China.
The timing of onsets is a critical factor in preventing disability in stroking patients. Developing a faster and more accurate diagnostic method is essential. Copeptin, as a stable surrogate for arginine vasopressin, has emerged as a novel and reliable serum biomarker for stroke.
View Article and Find Full Text PDFA Novel Pathogenic Variant of the Gene Leading to Arginine Vasopressin Resistance Since the Neonatal Period.
Genes (Basel)
August 2025
Department of Pediatrics and Endocrinology, Medical University of Warsaw, 02-091 Warsaw, Poland.
: Diabetes insipidus (DI) in newborns is an extremely rare condition, with the age of presentation strongly suggesting a genetic background of the disease. The differential diagnosis should include arginine vasopressin deficiency (AVD) and arginine vasopressin resistance (AVR). Some novel diagnostic tools such as copeptin evaluation and genetic tests are vital for early diagnosis.
View Article and Find Full Text PDFEvaluation of copeptin as a marker for the diagnosis of acute appendicitis in children.
Eur J Pediatr
August 2025
Paediatric Emergency Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Unlabelled: Copeptin has shown to correlate with acute appendicitis (AA) in adults. Its usefulness in the diagnosis of paediatric patients with suspected AA is unknown. The purpose of this study is to analyse the role of copeptin in the diagnosis of AA in children and to compare its diagnostic utility with other biomarkers.
View Article and Find Full Text PDF