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There is a growing demand for biomaterials developing with novel properties for biomedical applications hence, hydrogels with 3D crosslinked polymeric structures obtained from natural polymers have been deeply inspected in this field. Pectin a unique biopolymer found in the cell walls of fruits and vegetables is extensively used in the pharmaceutical, food, and textile industries due to its ability to form a thick gel-like solution. Considering biocompatibility, biodegradability, easy gelling capability, and facile manipulation of pectin-based biomaterials; they have been thoroughly investigated for various potential biomedical applications including drug delivery, wound healing, tissue engineering, creation of implantable devices, and skin-care products.
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http://dx.doi.org/10.1016/j.ijbiomac.2022.07.016 | DOI Listing |
Nat Aging
September 2025
Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.
Beyond their classical functions as redox cofactors, recent fundamental and clinical research has expanded our understanding of the diverse roles of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP) in signaling pathways, epigenetic regulation and energy homeostasis. Moreover, NAD and NADP influence numerous diseases as well as the processes of aging, and are emerging as targets for clinical intervention. Here, we summarize safety, bioavailability and efficacy data from NAD-related clinical trials, focusing on aging and neurodegenerative diseases.
View Article and Find Full Text PDFZhongguo Ying Yong Sheng Li Xue Za Zhi
September 2025
PSIT-Pranveer Singh Institute of Technology (Pharmacy), Kanpur - Agra - Delhi, NH#2, Bhauti, Kanpur, Uttar Pradesh, India.
Hemocyanin is dissolved freely in hemolymph, the invertebrate blood substitute, in contrast to haemoglobin, which is encased in red blood cells. When oxygenated, this pigment gives mollusc and arthropod blood its characteristic blue or purple hue. This review article delves into the fascinating biology of hemocyanin, the copper-based oxygen-carrying protein responsible for "purple blood" in many invertebrates, contrasting its characteristics with the more familiar iron-based hemoglobin.
View Article and Find Full Text PDFJMIR Res Protoc
September 2025
Academy for Health Innovation Uganda, Infectious Diseases Institute, Makerere University, Kampala, Uganda.
Background: Sexually transmitted infections are a significant public health concern, particularly in sub-Saharan Africa, where their prevalence remains high. Promoting awareness and reducing stigma are essential strategies for addressing this challenge, but those affected often have limited access to accurate and culturally appropriate health information. Therefore, innovative solutions are essential to enhance sexual health literacy and encourage informed health-seeking behaviors.
View Article and Find Full Text PDFAdv Drug Deliv Rev
September 2025
Biochemistry, CUNY Graduate Center, The City University of New York, 365 Fifth Avenue, New York, NY 10016, United States; Molecular, Cellular, and Developmental Biology, CUNY Graduate Center, The City University of New York, 365 Fifth Avenue, New York, NY 10016, United States; Chemistry, CUNY Gradua
Targeted drug delivery significantly enhances therapeutic efficacy across various diseases, particularly in cancer treatments, where conventional approaches such as chemotherapy and radiotherapy often cause severe side effects. In this context, nucleic acid aptamers-short, single-stranded DNA or RNA oligonucleotides capable of binding specific targets with high affinity-have emerged as promising tools for precision drug delivery and therapy. Aptamers can be selected against whole, living cells using SELEX and chemically modified for diverse applications.
View Article and Find Full Text PDFPhys Med Biol
September 2025
Zhejiang University, Zijingang Campus of Zhejiang University,Yuhangtang Road No.866,Zhejiang Province, China 310058, Hangzhou, Zhejiang, 310058, CHINA.
Transcranial ultrasound research has garnered significant attention due to its non-invasive nature, absence of ionizing radiation, and portability, making it advantageous for both imaging and therapy. A critical aspect of advancing transcranial research lies in understanding the ultrasound transmission performance of the human skull. However, inherent variations in skull shape, physical parameters, and age-related changes pose challenges for comparative studies.
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