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http://dx.doi.org/10.1002/ctm2.959 | DOI Listing |
Front Mol Biosci
August 2025
Department of Environmental Science, University of Arizona, Tucson, AZ, United States.
Introduction: Peatlands store up to a third of global soil carbon, and in high latitudes their litter inputs are increasing and changing in composition under climate change. Although litter significantly influences peatland carbon and nutrient dynamics by changing the overall lability of peatland organic matter, the physicochemical mechanisms of this impact-and thus its full scope-remain poorly understood.
Methods: We applied multimodal metabolomics (UPLC-HRMS, H NMR) paired with C Stable Isotope-Assisted Metabolomics (SIAM) to track litter carbon and its potential priming effects on both existing soil organic matter and carbon gas emissions.
J Hepatocell Carcinoma
August 2025
Department of Gastroenterology, Liver Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Purpose: Transarterial chemoembolization (TACE) may cause gut dysbiosis by increasing portal vein pressure. However, its association with clinical outcomes remains unknown. We hypothesized that gut microbiota composition and diversity are associated with treatment response and prognosis in patients with hepatocellular carcinoma (HCC) undergoing TACE.
View Article and Find Full Text PDFCureus
August 2025
Medical Education, Western Atlantic University School of Medicine, Freeport, BHS.
Mild cognitive impairment progresses slowly and may be reversible, providing a window of opportunity for intervention before it progresses to Alzheimer's disease, at which point treatments, at best, ameliorate symptoms with little efficacy towards delaying disease progression. The gut and brain communicate through the gut-brain axis, and derangement of the gut microbiome has been shown to promote neuroinflammation, a process intricately linked to pathological progression to mild cognitive impairment and subsequent neurocognitive diseases. In preclinical trials, probiotics modulated the gut microbiome in a way that was neuroprotective.
View Article and Find Full Text PDFFront Cell Infect Microbiol
September 2025
Laboratory of Jessica Galloway-Peña, Texas A&M University, Department of Veterinary Pathobiology, Interdisciplinary Graduate Program in Genetics and Genomics, College Station, TX, United States.
Introduction: Acute myeloid leukemia (AML) patients are highly susceptible to infection. Moreover, prophylactic and empirical antibiotic treatment during chemotherapy disrupts the gut microbiome, raising the risk for antibiotic-resistant (AR) opportunistic pathogens. There is limited data on risk factors for AR infections or colonization events in treated cancer patients, and no predictive models exist.
View Article and Find Full Text PDFJ Obes Metab Syndr
September 2025
Center of Excellence in Digestive diseases and Gastroenterology Unit, Department of Medicine, Thammasat University, Pathumthani, Thailand.
Background: The gut microbiota plays a vital role in various physiological processes, including metabolism. Fecal microbiota transplantation (FMT) involves transferring fecal matter from a healthy donor to rebalance a patient's intestinal dysbiosis. The impact of FMT on metabolic syndrome (MetS) is subject to debate.
View Article and Find Full Text PDF