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Article Abstract
Herein, we would like to present deoxyfluorinating reagents such as DAST and PyFluor and their successful use as tools for selective modification of γ-amino-α-hydroxyphosphonates. Depending on the deoxyfluorinating reagent applied, an intramolecular cyclization leading to phosphonates containing the 1,3-oxazinan-2-one moiety or direct nucleophilic deoxyfluorination yielding the α-fluorinated derivatives of γ-aminophosphonates was observed. The obtained compounds may be used as precursors in the preparation of medicinally important compounds , dipeptide analogues or scaffolds containing the 1,3-oxazinan-2-one group.
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