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The objective of this study was to encapsulate anthocyanins from red onion skins into different biopolymeric matrices as a way to develop powders with multifunctional activities. Two different variants of powders were obtained using a combination of gelation and freeze-drying techniques and characterized by encapsulation efficiency, antioxidant activity, phytochemical content, and color. Stability during storage and the bioavailability of anthocyanins in the in vitro simulated digestion were also examined. Powder V2, with a higher concentration of polysaccharides than V1, allowed a better encapsulation efficiency (90.53 ± 0.29%) and good stability during storage. Both variants had a high content of phytochemicals and antioxidant activity. In vitro investigations proved that an increased polysaccharides concentration offers the best protection for anthocyanins. Thus, a controlled release of the anthocyanins in the intestinal medium was achieved. The powder with the highest encapsulation efficiency was added to crackers, followed by phytochemical characterization to assess its potential added value. The addition of the micro-particles improved the functional characteristics such as antioxidant activity, showing its suitability for the development of bakery products. The attained results may bring implicit benefits to consumers, who can benefit from improved bioactive concentrations in foodstuffs, with significant health benefits.
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http://dx.doi.org/10.3390/antiox11061048 | DOI Listing |
Med Oncol
September 2025
Venom and Biotherapeutics Molecules Laboratory, Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.
Neuropeptide Y (NPY) and the voltage-gated potassium channel Kv1.3 are closely associated with breast cancer progression and apoptosis regulation, respectively. NPY receptors (NPYRs), which are overexpressed in breast tumors, contribute to tumor growth, migration, and angiogenesis.
View Article and Find Full Text PDFJ Am Chem Soc
September 2025
Life-like Materials and Systems, University of Mainz, Duesbergweg 10-14, 55128 Mainz, Germany.
Transmembrane signaling is essential for cellular communication, yet reconstituting such mechanisms in synthetic systems remains challenging. Here, we report a simple and robust DNA-based mechanism for transmembrane signaling in synthetic cells using cholesterol-modified single-stranded DNA (Chol-ssDNA). We discovered that anchored Chol-ssDNA spontaneously flips across the membrane of giant unilamellar lipid vesicles (GUVs) in a nucleation-driven, defect-mediated process.
View Article and Find Full Text PDFCompr Rev Food Sci Food Saf
September 2025
Department of Seafood Processing Technology, Faculty of Fisheries, Cukurova University, Adana, Turkey.
Microbial spoilage and oxidation are significant causes of food deterioration, contributing to food waste of up to 30%. To mitigate these losses, active food packaging is an effective solution. Considering the excellent properties of nanofibers produced by electrospinning, integrating active food packaging functionality with nanofiber technology offers an ideal approach enhancing preservation.
View Article and Find Full Text PDFAdv Pharm Bull
July 2025
Cell Therapy Center, The University of Jordan, 11942, Amman, Jordan.
Purpose: Breast cancer is the leading cause of cancer-related deaths among women. Chemotherapy faces challenges such as systemic toxicity and multidrug resistance. Advances in nanotechnology have led researchers to develop safer and more efficient cancer treatment methods.
View Article and Find Full Text PDFAdv Mater
September 2025
School of Physical Science and Technology, College of Energy, School of Optoelectronic Science and Engineering, Soochow University, Suzhou, 215000, P. R. China.
Polymer additives exhibit unique advantages in suppressing lead leaching from perovskite solar cells (PSCs). However, polymers tend to excessively aggregate in the perovskite film, which hinders comprehensive encapsulation and disrupts charge transport efficiency, degrading lead leakage inhibition and device performance. Herein, a polymer dynamic soft encapsulation strategy driven by molecular extrusion is introduced to mitigate lead leakage in PSCs, achieved through the incorporation of poly(propylene adipate) (PPA) as a multifunctional additive in the perovskite formulation.
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