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The aim of this article was to evaluate uterocervical angle (UCA) and cervical length (CL) measured at 16 to 24 weeks of gestation using transvaginal sonography (TVS) as predictors of spontaneous preterm birth. In this prospective study, TVS was performed in 159 primigravidas with a singleton, uncomplicated pregnancy at 16 to 24 weeks of gestation to measure the anterior UCA and CL. All the cases were followed until labor to document gestational age at delivery. The risk of spontaneous preterm birth was higher in women with obtuse UCA (>95 degrees) with sensitivity of 86.7%, specificity of 93.0%, positive predictive value of 83.0%, negative predictive value of 94.6%, and -value of <0.001. The difference between the means was statistically significant ( -value < 0.001). UCAs ≥105degrees and 95 to 105 degrees were found to be significantly associated with spontaneous preterm births at <34 weeks and 34 to 37 weeks, respectively. CL <2.5 cm was found to predict spontaneous preterm births at <37 weeks with sensitivity of 31.1%, specificity of 95.6%, and -value of <0.001. UCA was found to be a better predictor of spontaneous preterm birth with a higher coefficient of variation (56.4%) when compared with CL (16.9%). UCA proved to be a novel ultrasound parameter that can serve as a better predictor of spontaneous preterm births in comparison to CL. A strong correlation exists between obtuse UCA and a risk of spontaneous preterm birth.
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http://dx.doi.org/10.1055/s-0041-1741411 | DOI Listing |
NPJ Biofilms Microbiomes
September 2025
Imperial College Parturition Research Group, Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
The mechanisms by which vaginal microbiota shape spontaneous preterm birth (sPTB) risk remain poorly defined. Using electronic clinical records data from 74,913 maternities in conjunction with metaxanomic (n = 596) and immune profiling (n = 314) data, we show that the B blood group phenotype associates with increased risk of sPTB and adverse vaginal microbiota composition. The O blood group associates with sPTB in women who have a combination of a previous history of sPTB, an adverse vaginal microbial composition and pro-inflammatory cervicovaginal milieu.
View Article and Find Full Text PDFEcotoxicol Environ Saf
September 2025
College of Environment and Climate, Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou, Guangdong 510632, China.
Synthetic antioxidants and plasticizers have emerged as environmental contaminants to which prenatal exposure is widespread, raising concerns about adverse pregnancy outcomes. This study aimed to investigate the association between prenatal exposure to a mixture of synthetic antioxidants and plasticizers and the risk of spontaneous preterm birth (SPB), alongside underlying molecular responses. A nested case-control design was established, including 80 SPB cases and 170 matched healthy controls.
View Article and Find Full Text PDFArch Gynecol Obstet
September 2025
Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Objective: To investigate adverse pregnancy and delivery outcomes in women with GDMA1 during pregnancies conceived through fertility treatments.
Methods: This population-based retrospective cohort study examined adverse pregnancy and delivery outcomes in pregnancies affected by GDMA1 following fertility treatments compared to those conceived naturally. Women with GDMA1 who conceived via fertility treatments were classified as cases, while those who conceived naturally were designated as controls.
Khirurgiia (Mosk)
September 2025
Sevastopol City Hospital No. 5 - Center for Maternal and Child Health Protection, Sevastopol, Russia.
Objective: To analyze clinical data and predictors of mortality neonatal spontaneous gastric perforation (SGP).
Material And Methods: A two-center retrospective cohort study included neonates diagnosed with SGP between 1999 and 2023. This cohort was divided into survivors and dead neonates to identify prognostic factors of mortality.
Acta Obstet Gynecol Scand
September 2025
Paris Saclay University, UVSQ, Inserm, Team U1018, Clinical Epidemiology, CESP, Montigny-le-Bretonneux, France.
Introduction: We aimed to determine if women with a history of preterm labor successfully arrested by tocolytic treatment who gave birth at term in their previous pregnancy are at an increased risk of preterm delivery in their next pregnancy.
Material And Methods: This case-control study included women with two consecutive singleton pregnancies who gave birth in the 15-year period of 2000-2014 at the tertiary hospital of Poissy-Saint-Germain. Cases (preterm labor [PTL] group) included all women admitted with intact membranes for preterm labor that was successfully arrested by tocolytic treatment between 24 + 0 and 34 + 6 weeks' gestation and who gave birth at term in the first of these two pregnancies.