Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Glioblastomas are malignant tumors of the central nervous system hallmarked by subclonal diversity and dynamic adaptation amid developmental hierarchies. The source of dynamic reorganization within the spatial context of these tumors remains elusive. Here, we characterized glioblastomas by spatially resolved transcriptomics, metabolomics, and proteomics. By deciphering regionally shared transcriptional programs across patients, we infer that glioblastoma is organized by spatial segregation of lineage states and adapts to inflammatory and/or metabolic stimuli, reminiscent of the reactive transformation in mature astrocytes. Integration of metabolic imaging and imaging mass cytometry uncovered locoregional tumor-host interdependence, resulting in spatially exclusive adaptive transcriptional programs. Inferring copy-number alterations emphasizes a spatially cohesive organization of subclones associated with reactive transcriptional programs, confirming that environmental stress gives rise to selection pressure. A model of glioblastoma stem cells implanted into human and rodent neocortical tissue mimicking various environments confirmed that transcriptional states originate from dynamic adaptation to various environments.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ccell.2022.05.009 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Newly Established Anoikis-Associated Genes Predict the Prognosis of Hepatocellular Carcinoma.
J Hepatocell Carcinoma
September 2025
Department of Liver Disease, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China.
Objective: Anoikis is an anchorage-dependent programmed cell death implicated in multiple pathological processes of cancers; however, the prognostic value of anoikis-related genes (ANRGs) in hepatocellular carcinoma (HCC) remains unclear. Our study aims to develop an ANRGs-based prediction model to improve prognostic assessment in HCC patients.
Methods: The RNA-seq profile was performed to estimate the expression of ANRGs in HCC patients.
Analysis of tracrRNAs reveals subgroup V2 of type V-K CAST systems.
Microlife
August 2025
Faculty of Biology, Genetics and Experimental Bioinformatics, University of Freiburg, D-79104 Freiburg, Germany.
Clustered regularly interspaced palindromic repeats (CRISPR)-associated transposons (CAST) consist of an integration between certain class 1 or class 2 CRISPR-Cas systems and Tn7-like transposons. Class 2 type V-K CAST systems are restricted to cyanobacteria. Here, we identified a unique subgroup of type V-K systems through phylogenetic analysis, classified as V-K_V2.
View Article and Find Full Text PDFTranscriptome Analysis Reveals the Mechanism of Early Branching of Balsa (Ochroma lagopus Swartz).
Physiol Plant
September 2025
CAS Key Laboratory of Tropical Plant Resources and Sustainable Use, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Menglun, China.
Balsa (Ochroma lagopus Swartz), the world's lightest wood and a crucial material in wind turbine blades, holds significant potential to contribute to carbon neutrality efforts when cultivated in tropical areas such as Xishuangbanna, China. However, balsa trees planted in Xishuangbanna exhibit early branching, resulting in reduced wood yield. Our study investigated the pivotal factors in regulating shoot apical dominance and branching by comparing an early-branching cultivar from Indonesia with a late-branching cultivar from Ecuador.
View Article and Find Full Text PDFDaucosterol ameliorates acute inflammation and fibrosis following myocardial infarction via regulation of the ZBTB16 protein.
Br J Pharmacol
September 2025
Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Background And Purpose: Myocardial infarction (MI) is accompanied by acute release of numerous inflammatory factors, leading to fibrosis and ultimately cardiac dysfunction. Daucosterol (DAU), a natural sterol compound, has been demonstrated to have anti-inflammatory properties and the ability to mitigate liver fibrosis. This study aims to investigate the therapeutic potential of DAU in MI and explores the underlying mechanisms.
View Article and Find Full Text PDFExperiences and perspectives of professional caregivers on the transition of adults with intellectual and developmental disabilities: From the parental home to residential care facilities.
J Intellect Dev Disabil
September 2025
Applied Health Sciences Degree Program, Furtwangen University, Furtwangen, Germany.
Background: Few studies have examined how professional caregivers perceive the relocation of adults with intellectual and developmental disabilities from the family home to specialised residential settings.
Method: We conducted semi-structured interviews with eight professional caregivers, exploring their experiences of admitting adults with intellectual and developmental disabilities into residential care. Transcripts were analysed using Mayring's qualitative content analysis.