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Article Abstract

The goal of this case report is to identify the dental care of a patient who has co-occurrence of Treacher Collins and Down syndromes. It is the third case reported in the literature and the first relating dental treatment under general anesthesia and multidisciplinary importance. It was necessary the child's nutritional assessment in this case. This case highlights the importance of individualizing therapeutic protocols, due to the behavioral aspects of patients with special needs, optimizing treatment results in a single session under general anesthesia. Oral health is closely related to overall health, and it is important for awareness that the whole influences the success of medical treatment.

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http://dx.doi.org/10.1111/scd.12735DOI Listing

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The goal of this case report is to identify the dental care of a patient who has co-occurrence of Treacher Collins and Down syndromes. It is the third case reported in the literature and the first relating dental treatment under general anesthesia and multidisciplinary importance. It was necessary the child's nutritional assessment in this case.

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Article Synopsis
  • Orofacial clefts (OFCs) and clubfoot (CTEV) are congenital defects affecting facial and foot structure, with specific occurrence rates of 1 in 700 and 1 in 1000 live births, respectively.
  • * The study involved whole-exome sequencing of six individuals with both OFCs and CTEV to identify any common genetic causes.
  • * Four out of six probands exhibited probable pathogenic genetic variants, with each showing mutations in one to three different genes associated with various genetic syndromes.
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This is the first report of an individual with several congenital abnormalities, including those suggestive of Treacher Collins syndrome, and an atypical schizophrenic illness. Cytogenetic studies have failed to detect any recognizable chromosomal abnormality.

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