Determinants of Response to Cardiac Resynchronization Therapy.

J Innov Card Rhythm Manag

The Demoulas Center for Cardiac Arrhythmias, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.

Published: May 2022


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Article Abstract

Cardiac resynchronization therapy (CRT) is a well-established treatment modality for ambulatory patients with heart failure (HF) who have prolonged QRS, left bundle branch block, reduced left ventricular (LV) ejection fraction, and New York Heart Association class II-IV. CRT has been shown to induce reverse LV remodeling and improve HF symptoms and clinical outcomes. About one-third of CRT recipients are considered non-responders. Patient selection, LV lead location, LV lead selection, multipoint pacing, and optimization of the atrioventricular and ventriculo-ventricular intervals were all shown to be associated with a better CRT response rate. Herein, we review the determinants of CRT response.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9154012PMC
http://dx.doi.org/10.19102/icrm.2022.130503DOI Listing

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