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Background: For many co-manipulative applications, variable damping is a valuable feature provided by robots. One approach is implementing a high viscosity at low velocities and a low viscosity at high velocities. This, however, is proven to have the possibility to alter human natural motion performance.
Methods: We show that the distortion is caused by the viscosity drop resulting in robot's resistance to motion. To address this, a method for stably achieving the desired behaviour is presented. It involves leveraging a first-order linear filter to slow the viscosity variation down.
Results: The proposition is supported by a theoretical analysis using a robotic model. Meanwhile, the user performance in human-robot experiments gets significantly improved, showing the practical efficiency in real applications.
Conclusions: This paper discusses the variable viscosity control in the context of co-manipulation. An instability problem and its solution were theoretically shown and experimentally evidenced through human-robot experiments.
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http://dx.doi.org/10.1002/rcs.2416 | DOI Listing |
Med Eng Phys
October 2025
Department of Mechanical Engineering, University of Cape Town, 7701, South Africa; Centre for Research in Computational and Applied Mechanics (CERECAM), University of Cape Town, 7701, South Africa.
The usability and versatility of autoinjectors in managing chronic and autoimmune diseases have made them increasingly attractive in medicine. However, investigations into autoinjector designs require an understanding of the kinematic properties and fluid behaviour during injection. To optimise injection efficiency, this study develops a mathematical and computational fluid dynamics (CFD) model of an IM autoinjector by investigating the effects of viscosity, needle length, needle diameter, and medication volume on the injection process.
View Article and Find Full Text PDFFood Sci Biotechnol
October 2025
Department of Biosystems Engineering, Seoul National University, Seoul, 08826 Republic of Korea.
Unlabelled: This study was performed to evaluate the effects of added ingredients such as modified starch (MS), xanthan gum (XG), sugar, (SU), salt (SA), and vinegar (VIN) on the water mobility and physicochemical properties of model tomato ketchup and to investigate the correlation between the obtained variables and serum separation. The type and concentration of ingredients added to the tomato paste (TP) had significant effects on experimental variables, including the serum separation rate, water mobility, and viscosity. Serum separation was most severe in SU and VIN- added samples and minimal in MS and XG- added samples.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
National Center of Technology Innovation for Grain Industry (Comprehensive Utilization of Edible By-products), Beijing Technology & Business University, 100048, Beijing, China.; Key Laboratory of Geriatric Nutrition and Health (Beijing Technology and Business University), Ministry of Education, Beij
This study investigated the effects of steam exploration on soybean insoluble dietary fiber (U-IDF and M-IDF), and characterized the resulting stabilized Pickering emulsion. The particle size, ΔE, and water/oil holding capacity of M-IDF decreased, while its absolute value of zeta potential and contact angle increased. Significant changes in the intensities of the functional groups (-OH and CO) were observed in the Fourier transform infrared (FTIR) spectra of M-IDF.
View Article and Find Full Text PDFMAbs
December 2025
Antibody Discovery & Protein Engineering, Merck Healthcare KGaA, Darmstadt, Germany.
The discovery and development of multispecific antibodies present unique challenges in optimizing their physicochemical properties to enhance developability and manufacturability. Common developability challenges include increased risk of aggregation, high viscosity, poor solubility, low expression yields, complex purification requirements, greater propensity for fragmentation, immunogenicity, or pharmacokinetics. In this study, we systematically investigate the solution behavior of engineered bispecific IgG1-VHH constructs derived from a parental NKp30 ×EGFR natural killer cell engager (NKCE) molecule, focusing on colloidal stability, hydrophobicity, thermal stability, pH sensitivity, and viscosity.
View Article and Find Full Text PDFInt J Biol Macromol
August 2025
Department of Otorhinolaryngology, Head and Neck Surgery, Hannover Medical School, Hannover, Germany; Lower Saxony Center for Biomedical Engineering, Implant Research and Development (NIFE), Hannover Medical School, Hannover, Germany; Cluster of Excellence "Hearing4all", German Research Foundation,
The anatomical and structural complexity and variability of the hearing organ pose significant challenges for efficient drug delivery to treat inner ear disorders. To address this issue, we developed a local drug delivery implant (LDDI) fabricated with 3D printing technology. The implant is personalized based on the individual patient's anatomy of the round window niche from where drugs can diffuse into the inner ear.
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