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Background: Dermatofibrosarcoma protuberans (DFSP) is an uncommon, locally aggressive malignancy with wide local excision (WLE) or Mohs micrographic surgery (MMS) representing the treatment of choice. This article illustrates the experience of a single academic institution in treating DFSP with MMS and adds two particularly large, difficult closures of the glabella/central forehead and sternum to the body of literature.
Objective: To report the results of 15 patients with DFSP treated with MMS over a five-year period by a single Mohs surgeon at the University of Arkansas for Medical Sciences (UAMS).
Methods: A total of 15 patients between the ages of 16 and 80 years were diagnosed with DFSP and treated with MMS and were contacted in October 2021 to assess for recurrence.
Results: None of the 15 patients had a recurrence of DFSP following MMS, with a mean follow-up interval of 22.4 months and an average of 1.93 Mohs layers required for tumor clearance.
Conclusion: This experience reaffirms that MMS is an effective treatment for DFSP and adds additional examples of closure techniques of large, ovoid surgical defects on the glabella/central forehead and sternum to the literature.
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http://dx.doi.org/10.7759/cureus.24147 | DOI Listing |
Australas J Dermatol
September 2025
The Skin Hospital, Westmead, New South Wales, Australia.
Intravascular invasion of basal cell carcinoma is an exceedingly rare finding during Mohs' micrographic surgery. We present three cases and discuss its significance and management implications.
View Article and Find Full Text PDFJ Am Acad Dermatol
September 2025
Department of Dermatology, Hospital of the University of Pennsylvania; Philadelphia, PA. Electronic address:
Dermatol Surg
September 2025
HCA Florida Orange Park Hospital, Orange Park, Florida.
Background: Mohs micrographic surgery (MMS) allows for precise excision of skin cancers with intraoperative histologic margin assessment. Incidental findings-unexpected histopathologic features unrelated to the primary lesion-are occasionally discovered but scantily characterized in the literature.
Objective: To systematically review published cases of incidental histologic findings identified during MMS, with attention to their frequency, clinical implications, and management.
Postgrad Med J
September 2025
Department of Dermatology, Peking University First Hospital, No. 7 Xishiku Street, Xicheng, Beijing 100034, China.
Purpose: This retrospective study assessed the effectiveness of Mohs micrographic surgery (MMS) combined with adjuvant radiotherapy for the treatment of extramammary Paget's disease (EMPD).
Methods: This retrospective study included 87 patients with pathologically confirmed EMPD and complete follow-up data who were treated at the Radiation Therapy Department of Peking University First Hospital between January 2012 and December 2021. The surgical approach for the primary lesion involved MMS, followed by postoperative radiotherapy with doses ranging from 50 to 60 Gy administered over 25-30 fractions.
Dermatol Surg
September 2025
Epiphany Dermatology, Dallas, Texas.
Background: Bleeding remains a frequent complication during Mohs micrographic surgery, particularly among patients receiving anticoagulant or antiplatelet therapy. The growing use of these medications has prompted increased exploration of adjunctive methods to improve perioperative hemostasis.
Objective: To systematically review the literature on topically and locally administered hemostatic agents used to reduce bleeding in Mohs micrographic surgery.