Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Unlabelled: Existing literature has demonstrated the significant relationship between race and kidney transplant outcomes; however, there are conflicting and limited data on the influence of donor race or donor-recipient race-matching on pediatric kidney transplant outcomes.
Methods: Analysis included kidney-only transplant recipients between ages 2 and 17 from 2000 to 2017 enrolled in the Organ Procurement and Transplantation Network and their associated donors. Multivariable regression models were used to compare outcomes by donor race and donor-recipient race-matched status.
Results: Of the total 7343 recipients, 4458 (60.7%) recipients received a kidney from a White donor, 1009 (13.7%) from a Black donor, 1594 (21.7%) from Hispanic donor, and 169 (4.1%) from an Asian donor; 4089 (55.7%) were race-matched. No donor races were significantly associated with transplant outcomes (all > 0.05). Race-matched status was not associated with graft failure (hazard ratio, 1.03; 95% confidence interval [CI] = 0.89-1.2; = 0.68), mortality (hazard ratio, 1.1; 95% CI, 0.79-1.53; = 0.56), acute rejection at 1 y (odds ratio, 0.94; 95% CI, 0.77-1.15; = 0.53), or delayed graft function (odds ratio, 1.02; 95% CI, 0.80-1.29; = 0.91).
Conclusions: Neither donor race nor race-matched status is associated with better transplant outcomes. Further studies are necessary to confirm the impact of donor race and race-matching more fully on pediatric kidney transplant outcomes.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9088235 | PMC |
| http://dx.doi.org/10.1097/TXD.0000000000001324 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Ante-Mortem Clinical Characterization with Post-Mortem Family Interview and Medical Record Abstraction in a Traumatic Brain Injury Brain Donor Program.
Neurotrauma Rep
August 2025
Department of Rehabilitation and Human Performance, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Recent investments in large-scale mortem tissue collection have accelerated opportunities to understand the neuropathology of traumatic brain injury (TBI) and post-traumatic neurodegeneration (PTND). Clinicopathological correlation requires ante-mortem clinical information. Post-mortem family interviews (PFIs) are an established method to capture comprehensive ante-mortem clinical information.
View Article and Find Full Text PDFAssociation Between UGT1A1 mRNA Expression and Cis-Acting Genetic Variants and Trans-Acting Transcriptional Regulators in Human Liver Samples.
Genes (Basel)
August 2025
Department of Pharmacotherapy and Translational Research, College of Pharmacy, Center for Pharmacogenomics and Precision Medicine, University of Florida, Gainesville, FL 32610, USA.
UDP-glucuronosyltransferase 1A1 (UGT1A1) metabolizes endogenous substances and pharmaceuticals. Genetic polymorphisms, particularly TA repeats in the UGT1A1 promoter TATA region (UGT1A1*28/*36/*37) and a nearby single-nucleotide polymorphism (SNP) rs887829, are associated with UGT1A1-related phenotypes and used as biomarkers for guiding drug therapy. However, these associations are inconsistent, especially in individuals of African ancestry.
View Article and Find Full Text PDFDonor-Recipient Race Mismatch Is Associated with Lower Survival After Liver Transplantation for Primary Sclerosing Cholangitis.
J Clin Med
August 2025
Division of Hepatology, Department of Medicine, Atrium Health Wake Forest, Charlotte, NC 28204, USA.
Patient survival after liver transplantation is lower in donor-recipient race mismatched patients for indications other than primary sclerosing cholangitis. : To determine if survival is lower after liver transplantation in donor-recipient race mismatched recipients with primary sclerosing cholangitis. : The Organ Procurement and Transplantation Network database was analyzed for deceased donor adult liver transplant recipients with primary sclerosing cholangitis.
View Article and Find Full Text PDFIs Active Purulence Associated With the Success of Particulate Autogenous Bone Grafting in the Reconstruction of Post-traumatic Mandibular Defects? A Retrospective Cohort Study.
J Oral Maxillofac Surg
July 2025
Professor, School of Dental Medicine, Tufts University, Boston, MA.
Background: Bone defects following post-traumatic mandibular injuries represent a reconstructive challenge when active purulence is present. While particulate autogenous bone grafts are commonly used, their effectiveness in this context remains uncertain.
Purpose: The purpose of this study was to measure the association between active purulence and grafting success in post-traumatic mandibular defects reconstructed using particulate autogenous bone.
Mid-pregnancy circulating placental growth factor (PlGF) and obstetrical outcomes following nonovulatory and ovulatory frozen embryo transfer cycles.
J Assist Reprod Genet
August 2025
Maternal-Fetal Medicine, Department of Obstetrics and Gynaecology, Mount Sinai Hospital, University of Toronto, 700 University Ave, Toronto, ON, M5G 1Z5, Canada.
Purpose: We compared serum placental growth factor (PlGF) concentration in pregnancies from ovulatory vs. non-ovulatory FET cycles and evaluated associations with obstetrical and neonatal outcomes.
Methods: We conducted a secondary analysis of a prospective single-center screening study at a large urban center in Canada where PlGF was performed between April 2020 and December 2022.